PMID: 53049Jun 1, 1975

Effects of thymus-independent (B) cells and the H-2 gene complex on antiviral function of immune thymus-derived (T) cells

The Australian Journal of Experimental Biology and Medical Science
R V BlandenC R Parish

Abstract

Antiviral activity in vivo exerted by ectromelia virus-immune spleen cells transferred to ectromelia-infected recipients and cytotoxicity against virus-infected target cells in vitro were both properties of non-immunoglobulin (Ig)-bearing cells (which included T cells). Ig-bearing cells, including thymus-independent (B) cells and antibody-secreting cells, were much less active in vivo when injected alone and tended to block rather than amplify the effect triggered by T cells. Ig-bearing cells were also slightly active in vitro, possibly because some T cells have detectable Ig. Antiviral effects in cell transfer experiments were seen only when immune cell donors and infected recipients shared the same H-2 gene complex. These results are consistent with the hypothesis that the T cell response to ectromelia infection is directed against specific virus-induced change(s) in antigen(s), specified by gene(s) in the H-2 complex, which appear in virus-infected cells.

Citations

Feb 1, 1976·The Journal of Experimental Medicine·U Kees, R V Blanden
Mar 1, 1987·Parasite Immunology·S P NickellG A Cole

Related Concepts

Antigenic Specificity
B-Lymphocytes
Microcytotoxicity Test
Ectromelia, Infectious
Cistron
Histocompatibility
SD Antigens
Cellular Immune Response
Normal Serum Globulin Therapy
Immunoglobulins

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