Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
C H GouveiaA C Bianco

Abstract

To investigate the effects of thyroxine (T4) administration on bone mass, five 81-day-old female rats were treated with T4 (25 microg of T4/100 g of body weight [bw]/day), and bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) 28 days later. The BMD values for the total skeleton, femoral, and tibial subsegments were lower than in controls (p < or = 0.05). The lumbar spine (L2-L5) was not significantly affected by T4 treatment. Next, thirty-seven 211 +/- 1.5 (mean +/- SEM)-day-old female rats were divided into six groups as follows: (1) control; (2) ovariectomized (OVX); (3) 1xT4 (approximately 1.0 microg of T4/100 g of bw/day; approximately physiological replacement dose); (4) OVX + 1xT4; (5) 2xT4 (approximately 2.0 microg of T4/100 g of bw/day); (6) OVX + 2xT4. DXA scans were performed at days 0 and 85. Control rats showed a generalized BMD increase, as opposed to a decrease in OVX rats. The trabecular bone volume of the fifth lumbar vertebra was also lower in OVX rats than in controls (p < 0.05). The 1xT4 treatment had no effect on BMD of intact rats, while treatment with 2xT4 impaired the expected BMD increase. Unexpectedly, the OVX + 1xT4 group presented a generalized BMD increase that was sig...Continue Reading

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Citations

Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Cecilia H GouveiaGregory A Brent
Jun 11, 2005·Cell and Tissue Research·Elen H MiyabaraAnselmo S Moriscot
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Sep 4, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tatiana L FonsecaCecilia H Gouveia
Jun 7, 2013·PloS One·Wagner S VicenteVanda Jorgetti
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Nov 12, 2005·Bioscience Reports·Antonio C BiancoMarcelo A Christoffolete
Aug 17, 2019·Jornal brasileiro de nefrologia : ʹorgão oficial de Sociedades Brasileira e Latino-Americana de Nefrologia·Bárbara Bruna Abreu de CastroHelady Sanders-Pinheiro
Jul 10, 2014·American Journal of Physiology. Endocrinology and Metabolism·Tatiana L FonsecaCecilia H A Gouveia
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Cecília H A Gouveia
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Jul 3, 2019·Thyroid : Official Journal of the American Thyroid Association·Bianca Neofiti-PapiCecilia H A Gouveia
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Rogéria SerakidesErnane F do Nascimento

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