Effects of Thyroid Hormone on Urinary Concentrating Ability

European Thyroid Journal
Elske T MassoltRobin P Peeters

Abstract

Hypothyroidism has been associated with impaired urinary concentrating ability. However, previous reports on thyroid hormone and urinary concentrating ability in humans only studied a limited number of patients with autoimmune thyroid disease or used healthy controls instead of paired analysis within the same patients. To study the urinary concentrating ability in athyreotic patients with differentiated thyroid cancer on and off levothyroxine treatment as they are exposed to different thyroid states as part of their treatment in the absence of an autoimmune disease. We studied 9 patients (mean age of 42.7 years) during severe hypothyroid state (withdrawal of levothyroxine before radioactive iodine therapy) and TSH-suppressed state (on levothyroxine therapy). At these two points, serum and urine samples were collected after 14 h of overnight fasting without any food or drink. Serum and urine osmolality were not significantly different between on and off levothyroxine treatment. Serum creatinine levels were significantly higher in patients off versus on levothyroxine treatment (87.0 vs. 71.0 µmol/L, respectively; p = 0.044) and, correspondingly, the estimated glomerular filtration rate was significantly lower (89.6 vs. 93.1 mL/mi...Continue Reading

References

Jul 1, 1976·Kidney International·G L RobertsonS Athar
Mar 1, 1971·The American Journal of Medicine·V A Discala, M J Kinney
Sep 1, 1994·Clinical Science·F VargasJ García-Estañ
Feb 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J MontenegroI Martínez
Jan 19, 1999·Archives of Internal Medicine·S H Kreisman, J V Hennessey
Oct 16, 1999·The American Journal of the Medical Sciences·C VillabonaJ Soler
Mar 1, 2000·Archives of Internal Medicine·G J CanarisE C Ridgway
Feb 15, 2001·The New England Journal of Medicine·I Klein, K Ojamaa
Feb 22, 2003·Journal of the American Society of Nephrology : JASN·Melissa A CadnapaphornchaiRobert W Schrier
Dec 20, 2003·American Journal of Nephrology·Georgios KaranikasKurt Kletter
Mar 16, 2004·Lancet·Caroline G P Roberts, Paul W Ladenson
May 26, 2005·American Journal of Physiology. Renal Physiology·Yung-Chang ChenRobert W Schrier
Aug 22, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Martin SchlumbergerFurio Pacini
Oct 25, 2011·Journal of the American Society of Nephrology : JASN·Laura H Mariani, Jeffrey S Berns
Dec 12, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Mireille El TersSuzanne M Norby
Jun 30, 2015·Clinical Endocrinology·Josephine H LiJames V Hennessey
Jul 15, 2015·The New England Journal of Medicine·Mark A KnepperSoren Nielsen
Jul 15, 2015·The New England Journal of Medicine·Johann MorelleOlivier Devuyst

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Citations

Nov 23, 2021·Thyroid : Official Journal of the American Thyroid Association·Rutchanna M S JongejanYolanda B de Rijke

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