Effects of thyroid hormones, antithyroid drugs and iodide on in vitro conversion of thyroxine to triiodothyronine

Clinical and Experimental Pharmacology & Physiology
T Aizawa, T Yamada

Abstract

In an attempt to study the effects of thyroid hormones, antithyroid drugs and iodide on the conversion of thyroxine (T4) to triiodothyronine (T3), the liver was obtained from normal, hypothyroid and hyperthyroid rats treated with T4 or T3 . T4 was incubated with liver homogenates and generated T3 was measured. 1. The conversion of T4 to T3 was less in the liver homogenates from thyroidectomized, methylmercaptoimidazole (MMI)-treated and propylthiouracil (PTU)-treated rats. The magnitude of decrease was the same in thyroidectomized and MMI-treated rats, but was greater in PTU-treated rats. 2. Administration of T4 and T3 to thyroidectomized and MMI-treated rats restored the converting activity. When excess T4 was administered, the converting activity was above normal. In contrast, administration of graded doses of T4 failed to restore the converting activity of the liver from PTU-treated rats. 3. In vitro addition of MMI failed to affect converting activity of the liver, but addition of excess iodide and PTU significantly depressed it.

References

Sep 1, 1978·The Journal of Clinical Endocrinology and Metabolism·T AizawaK Yoshizawa
Jan 1, 1977·Annual Review of Medicine·R R Cavalieri
Feb 1, 1978·Endocrinology·P ChiraseveenuprapundI N Rosenberg
Nov 1, 1967·Endocrinology·P V TishlerS H Ingbar
Dec 1, 1966·Metabolism: Clinical and Experimental·I KobayashiK Shichijo
Jun 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·H D Battarbee, W J Schindler
Jun 1, 1971·The Journal of Clinical Investigation·C S PittmanV H Read
Mar 1, 1952·Lancet·J GROSS, R PITT-RIVERS

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Citations

Jun 1, 1983·British Journal of Pharmacology·E J Ishac, J N Pennefather
Mar 1, 1994·Journal of Veterinary Internal Medicine·D M VailG K Ogilvie
May 1, 1985·Postgraduate Medical Journal·M R WilkinsM J Kendall

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