PMID: 3752238Sep 1, 1986Paper

Effects of thyroid hormones on calcium contents and 45Ca exchange in rat skeletal muscle

The American Journal of Physiology
M E Everts, T Clausen

Abstract

In 4-wk-old rats, pretreatment with L-triiodothyronine (T3) increased calcium content by 100% and the 30-min 45Ca uptake by 64% in the soleus, whereas the extensor digitorum longus (EDL) muscle showed no significant change. The stimulation of 45Ca uptake was resistant to dantrolene and methoxyverapamil (D600) and could not be attributed to altered permeability of the plasma membrane to calcium, but appears to reflect increased net accumulation of calcium in intracellular pools. The stimulating effect of high K0 (20 mM) on 45Ca uptake was more pronounced in soleus than in EDL and could be suppressed by dantrolene and D600. The results indicate that the effects of T3 on calcium content and 45Ca exchange are primarily exerted on muscles containing a large proportion of slow-twitch, oxidative fibers. In soleus muscle from hyperthyroid rats the stimulating effects of high K0 on 45Ca uptake and lactate production were, respectively, 3.4 and 4.5 times larger than in those obtained from controls. These observations further support the earlier proposed idea [C. van Hardeveld and T. Clausen. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E421-E430, 1984] that the metabolic effects of thyroid hormone depend on the availability of cellular a...Continue Reading

References

Jul 1, 1985·The Journal of Physiology·D Kim, T W Smith
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Nov 1, 1969·The Journal of Clinical Investigation·B L Fanburg
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Citations

Dec 17, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K T MurphyT Clausen
Jul 3, 2015·Physiological Reviews·O FriedrichL Larsson
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H Gissel, T Clausen
Sep 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einav Yehuda-ShnaidmanJacob Bar-Tana
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla Ramer MikkelsenTorben Clausen
Oct 23, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F A VerhoevenM E Everts
Dec 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Anne Lene Dalkjaer RiisTorben Clausen
Oct 2, 2001·The Journal of Physiology·O B NielsenK Overgaard

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