PMID: 11927393Apr 3, 2002Paper

Effects of thyroid hormones on pulmonary and renal angiotensin-converting enzyme concentrations in fetal sheep near term

The Journal of Endocrinology
Alison J Forhead, Abigail L Fowden

Abstract

In the sheep fetus, pulmonary and renal concentrations of angiotensin-converting enzyme (ACE) increase towards term in parallel with the prepartum surges in plasma cortisol and tri-iodothyronine (T(3)). The ontogenic change in pulmonary ACE has been shown to be induced, at least in part, by cortisol but the role of the thyroid hormones is unknown. Therefore, this study investigated the effects of thyroid hormones on tissue ACE concentration in fetal sheep during late gestation. Pulmonary and renal ACE concentrations were measured in sheep fetuses after experimental manipulation of thyroid hormone status by fetal thyroidectomy and exogenous hormone infusion. In intact fetuses, pulmonary and renal ACE concentrations increased between 127-132 and 142-145 days of gestation (term 145 +/- 2 days), coincident with the prepartum rises in plasma cortisol and T(3). The ontogenic increment in pulmonary ACE concentration was abolished when the prepartum surge in T(3), but not cortisol, was prevented by fetal thyroidectomy. At 143-145 days, ACE concentration in the lungs and kidneys of the thyroidectomised fetuses were both lower than those in the intact fetuses. In intact fetuses at 127-132 days, pulmonary ACE was upregulated by intravenou...Continue Reading

Citations

Oct 7, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Natasha N ChattergoonKent L Thornburg
Mar 22, 2014·The Journal of Endocrinology·A J Forhead, A L Fowden
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Michelle A KutzlerP W Nathanielsz
Mar 3, 2009·Experimental Physiology·Abigail L Fowden, Alison J Forhead
Nov 25, 2003·American Journal of Obstetrics and Gynecology·Heiner ZimmermannAlison J Forhead
May 30, 2006·Peptides·M S Carneiro-RamosM L M Barreto-Chaves
May 28, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kai ChenJames C Rose
Oct 20, 2015·Endocrinology·M J De BlasioA J Forhead
Aug 28, 2019·Journal of Molecular Evolution·Iordanis MourouzisChristodoulos Xinaris

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