Abstract
Previous studies addressing the influence of thyroid hormones on serum levels of adipokines yielded conflicting results. We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model. Twenty-two women with differentiated thyroid carcinoma were studied the last day of their thyroxine-suppressive treatment, 4-7 days after withdrawal, and the day before whole-body scanning. Evaluations included serum thyroid hormone, leptin, resistin, and adiponectin concentrations, fasting glucose and insulin, lipid profiles, body temperature, body mass index, and total body fat mass. Thyroid function changed from subclinical or mild hyperthyroidism to normal free thyroxine and triiodothyronine levels, ending in overt hypothyroidism. Thyroxine withdrawal resulted in an increase in serum resistin (p = 0.007) and leptin (p = 0.006) concentrations, whereas adiponectin levels remain unchanged. A significant decrease in body temperature during thyroxine withdrawal was paralleled by a decrease in fasting glucose (p = 0.006) and insulin resistance (p = 0.033), which occurred despite an increase in estimated total body fat mass. Thyroid hormones are important regulators of ener...Continue Reading
References
Jan 1, 1978·Endocrinology·S P Singh, A K Snyder
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M P SandlerN N Abumrad
Feb 1, 1996·European Journal of Endocrinology·M WolfG Kreymann
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·R S Ahima, J S Flier
Jan 1, 2003·Biochemical and Biophysical Research Communications·John N FainM Lloyd Hiler
Mar 14, 2003·Obesity Research·Rubén NogueirasCarlos Diéguez
Jun 5, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G Boden
Aug 6, 2003·Annals of Internal Medicine·J Enrique Silva
Sep 30, 2003·European Journal of Endocrinology·Tina Zimmermann-BelsingUlla Feldt-Rasmussen
Nov 18, 2003·Clinical Endocrinology·Pedro IglesiasJuan J Díez
Jan 10, 2004·Endocrine-related Cancer·J I Botella-CarreteroH F Escobar-Morreale
Jan 17, 2004·Endocrinology·John N FainSuleiman W Bahouth
Mar 31, 2004·Journal of Internal Medicine·Claire M Steppan, Mitchell A Lazar
May 28, 2004·Endocrine-related Cancer·José I Botella-CarreteroHéctor F Escobar-Morreale
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Sep 17, 2004·Journal of Cellular Biochemistry·Subhashini YaturuSidney R Grimes
Oct 16, 2004·Obesity Research·Yaoting GuiLiam J Murphy
Jan 25, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcos F Dall'OglioMiguel Srougi
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi
Aug 3, 2005·European Journal of Endocrinology·José I Botella-CarreteroHéctor F Escobar-Morreale
Citations
Aug 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·M LusterUNKNOWN European Association of Nuclear Medicine (EANM)
Nov 13, 2010·Endocrine·Vaia LambadiariGeorge Dimitriadis
Dec 1, 2011·Journal of Physiology and Biochemistry·Samira SeifiParisa Sarkoohi
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Nikolaos Pontikides, Gerasimos E Krassas
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Ulla Feldt-Rasmussen
Apr 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Dilek Gogas YavuzSema Akalin
May 10, 2008·Thyroid : Official Journal of the American Thyroid Association·Mariusz BraclikArkadiusz Orzeł
Mar 23, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Duygu Yazgan AksoyMiyase Bayraktar
May 13, 2008·Endocrine Journal·Ching-Jung Hsieh, Pei-Wen Wang
May 29, 2014·World Journal of Surgery·Rania Abdel RehemTarek Ezzat Abdel-Aziz
Nov 7, 2009·Asian Journal of Surgery·Melih AkinciAbdullah Cetin
May 21, 2013·Archives of Medical Research·Bulent Okan YildizMiyase Bayraktar
Jan 21, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Jordi L Reverter, Eulàlia Colomé
May 25, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Jordi L ReverterAnna Sanmartí
Sep 22, 2009·Metabolism: Clinical and Experimental·Shih-Yi LinWayne Huey-Herng Sheu
Nov 17, 2007·Cytokine·Pedro Iglesias, Juan J Díez
Sep 24, 2015·Wiener klinische Wochenschrift·Gulhan AkbabaSerdar Guler
Jul 21, 2015·Metabolism: Clinical and Experimental·Jung Ah LimYoung Joo Park
Mar 28, 2013·Journal of Thyroid Research·Ceren Eke KoyuncuYüksel Gülen Ozbanazi
Sep 18, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ozlem KaplanNese Colak Ozbey
May 26, 2010·Yonsei Medical Journal·Hyuk-Jae ChangYoung Joo Park
May 20, 2016·Scientific Reports·Yanyan ChenYuanyuan Xu
Dec 15, 2000·Surgery·A FrillingC E Broelsch
Nov 20, 2016·The Journal of International Medical Research·Jee Hyun AnSuk Kyeong Kim
Sep 16, 2018·Endocrine·Eunice NyasaniSalma Khan
Apr 26, 2013·Neurologia Medico-chirurgica·Toshihide TanakaToshiaki Abe
Jan 7, 2011·Maternal and Child Health Journal·Glenys M WebsterPatricia A Janssen
Oct 17, 2009·Journal of Endocrinological Investigation·F SaraçC Yilmaz
Nov 22, 2018·Archives of Endocrinology and Metabolism·Bruna Karoline Lima PiazeraMário Vaisman
Feb 5, 2013·Molecular and Cellular Biochemistry·Samira SeifiMehdi Saeb
Feb 9, 2017·Journal of Physical Therapy Science·Sung-Hyun Park, MinYoung Song
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity