Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal

Thyroid : Official Journal of the American Thyroid Association
José I Botella-CarreteroHéctor F Escobar-Morreale

Abstract

Previous studies addressing the influence of thyroid hormones on serum levels of adipokines yielded conflicting results. We aimed to study the impact of short-term overt hypothyroidism on serum leptin, resistin, and adiponectin levels in an in vivo human model. Twenty-two women with differentiated thyroid carcinoma were studied the last day of their thyroxine-suppressive treatment, 4-7 days after withdrawal, and the day before whole-body scanning. Evaluations included serum thyroid hormone, leptin, resistin, and adiponectin concentrations, fasting glucose and insulin, lipid profiles, body temperature, body mass index, and total body fat mass. Thyroid function changed from subclinical or mild hyperthyroidism to normal free thyroxine and triiodothyronine levels, ending in overt hypothyroidism. Thyroxine withdrawal resulted in an increase in serum resistin (p = 0.007) and leptin (p = 0.006) concentrations, whereas adiponectin levels remain unchanged. A significant decrease in body temperature during thyroxine withdrawal was paralleled by a decrease in fasting glucose (p = 0.006) and insulin resistance (p = 0.033), which occurred despite an increase in estimated total body fat mass. Thyroid hormones are important regulators of ener...Continue Reading

References

Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·M P SandlerN N Abumrad
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·R S Ahima, J S Flier
Jan 1, 2003·Biochemical and Biophysical Research Communications·John N FainM Lloyd Hiler
Mar 14, 2003·Obesity Research·Rubén NogueirasCarlos Diéguez
Jun 5, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G Boden
Aug 6, 2003·Annals of Internal Medicine·J Enrique Silva
Sep 30, 2003·European Journal of Endocrinology·Tina Zimmermann-BelsingUlla Feldt-Rasmussen
Jan 10, 2004·Endocrine-related Cancer·J I Botella-CarreteroH F Escobar-Morreale
Mar 31, 2004·Journal of Internal Medicine·Claire M Steppan, Mitchell A Lazar
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Sep 17, 2004·Journal of Cellular Biochemistry·Subhashini YaturuSidney R Grimes
Jan 25, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Marcos F Dall'OglioMiguel Srougi
May 18, 2005·Endocrine Reviews·Takashi Kadowaki, Toshimasa Yamauchi

❮ Previous
Next ❯

Citations

Aug 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·M LusterUNKNOWN European Association of Nuclear Medicine (EANM)
Dec 1, 2011·Journal of Physiology and Biochemistry·Samira SeifiParisa Sarkoohi
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Nikolaos Pontikides, Gerasimos E Krassas
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Ulla Feldt-Rasmussen
Apr 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Dilek Gogas YavuzSema Akalin
May 10, 2008·Thyroid : Official Journal of the American Thyroid Association·Mariusz BraclikArkadiusz Orzeł
Mar 23, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Duygu Yazgan AksoyMiyase Bayraktar
May 29, 2014·World Journal of Surgery·Rania Abdel RehemTarek Ezzat Abdel-Aziz
Nov 7, 2009·Asian Journal of Surgery·Melih AkinciAbdullah Cetin
Jan 21, 2011·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Jordi L Reverter, Eulàlia Colomé
May 25, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Jordi L ReverterAnna Sanmartí
Nov 17, 2007·Cytokine·Pedro Iglesias, Juan J Díez
Jul 21, 2015·Metabolism: Clinical and Experimental·Jung Ah LimYoung Joo Park
Mar 28, 2013·Journal of Thyroid Research·Ceren Eke KoyuncuYüksel Gülen Ozbanazi
Sep 18, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ozlem KaplanNese Colak Ozbey
Apr 26, 2013·Neurologia Medico-chirurgica·Toshihide TanakaToshiaki Abe
Jan 7, 2011·Maternal and Child Health Journal·Glenys M WebsterPatricia A Janssen
Oct 17, 2009·Journal of Endocrinological Investigation·F SaraçC Yilmaz
Nov 22, 2018·Archives of Endocrinology and Metabolism·Bruna Karoline Lima PiazeraMário Vaisman
Feb 5, 2013·Molecular and Cellular Biochemistry·Samira SeifiMehdi Saeb
Feb 9, 2017·Journal of Physical Therapy Science·Sung-Hyun Park, MinYoung Song
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.