Effects of thyroid replacement therapy on arterial blood pressure in patients with hypertension and hypothyroidism

American Heart Journal
John Dernellis, Maria Panaretou

Abstract

Hypothyroidism is frequently accompanied by cardiac dysfunction, increased vascular resistance, and a greater prevalence of hypertension. Treatment of hypothyroidism may lead to normalization of blood pressure, although some patients may exhibit sustained hypertension. The mechanism of this condition may be the alterations in aortic stiffness. Aortic stiffness was studied in 30 patients who never received treatment for hypertension or hypothyroidism, 15 patients with normal blood pressure and hypothyroidism, and 15 patients with hypertension and normal thyroid function. Thirty healthy age- and sex-matched subjects with normal thyroid function served as control subjects. Aortic diameter evaluated by M-mode echocardiography and blood pressure measured by a sphygmomanometer were used to calculate aortic stiffness index. Patients with high blood pressure and hypothyroidism, those with normal blood pressure and hypothyroidism, and those with hypertension and normal thyroid function showed increased aortic stiffness index (18.8 +/- 6.4, 11.7 +/- 3.5, and 19.2 +/- 5.3 vs 9.5 +/- 2.7; P <.001) compared with control subjects. In 15 patients with hypertension and hypothyroidism, levothyroxine therapy showed only a small decrease in blood...Continue Reading

Citations

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