PMID: 1203323Jan 1, 1975Paper

Effects of thyroidectomy of the rat on the structure and functions of skeletal muscle mitochondria

Biochimie
J BouhnikR Michel

Abstract

Mitochondria used in the present study were isolated from skeletal muscle of normal and thyroidectomized rats. The preparations were controlled by electron microscopy. It was not possible to find any morphological change induced by thyroidectomy, nevertheless, some difference appeared in the cytochrome contents which were slightly decreased. Oxygen consumption rates of thyroidectomized rat mitochondria were decreased when the particles were maintained in states 3 and 4 in the presence of various substrates, but the P/O ratios were not modified. The activities of mitochondrial enzymes were in general slightly affected by thyroidectomy except for glycerol-1-phosphate cytochrome c reductase and NADH rotenone sensitive cytochrome c reductase which were decreased and for glutamate dehydrogenase activity which was increased. The tRNA nucleotidyltransferase activity found in the mitochondrial matrix was not influenced by the absence of thyroid secretion. Normal rat muscle mitochondria incorporate 14C-leucine with an artificial ATP-generating system or with a respiratory substrate. The amino acid incorporation was decreased by thyroidectomy. Muscle mitochondria analyzed by polyacrylamide gel electrophoresis contained more than 30 prote...Continue Reading

References

Sep 1, 1972·Biochimica Et Biophysica Acta·H Hayashi, R A Capaldi
Oct 1, 1972·European Journal of Biochemistry·M N GadaletaC Saccone
Feb 22, 1973·Biochimica Et Biophysica Acta·G R BullockA M White
Jun 1, 1971·Biochimica Et Biophysica Acta·T K Ray, G V Marinetti
Sep 22, 1971·Biochimica Et Biophysica Acta·L Susheela, T Ramasarma
Mar 20, 1968·Archives of Biochemistry and Biophysics·F L Hoch
Mar 1, 1966·Biochemistry·D S BeattieS B Koritz
Mar 1, 1963·The Biochemical Journal·J R TATAR HEDMAN

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