Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats

American Journal of Physiology. Endocrinology and Metabolism
Lars P KlieverikEric Fliers

Abstract

Thyrotoxicosis is known to induce a broad range of changes in carbohydrate metabolism. Recent studies have identified the sympathetic and parasympathetic nervous system as major regulators of hepatic glucose metabolism. The present study aimed to investigate the pathogenesis of altered endogenous glucose production (EGP) in rats with mild thyrotoxicosis. Rats were treated with methimazole in drinking water and l-thyroxine (T(4)) from osmotic minipumps to either reinstate euthyroidism or induce thyrotoxicosis. Euthyroid and thyrotoxic rats underwent either a sham operation, a selective hepatic sympathetic denervation (Sx), or a parasympathetic denervation (Px). After 10 days of T(4) administration, all animals were submitted to a hyperinsulinemic euglycemic clamp combined with stable isotope dilution to measure EGP. Plasma triiodothyronine (T(3)) showed a fourfold increase in thyrotoxic compared with euthyroid animals. EGP was increased by 45% in thyrotoxic compared with euthyroid rats and correlated significantly with plasma T(3). In thyrotoxic rats, hepatic PEPCK mRNA expression was increased 3.5-fold. Relative suppression of EGP during hyperinsulinemia was 34% less in thyrotoxic than in euthyroid rats, indicating hepatic insu...Continue Reading

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Citations

May 28, 2013·Trends in Molecular Medicine·Miguel LópezCarlos Diéguez
Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lars P KlieverikAndries Kalsbeek
Jul 13, 2011·The Journal of Endocrinology·L A SantiagoT M Ortiga-Carvalho
Aug 29, 2009·The Journal of Endocrinology·Beatriz S AmorimMiriam O Ribeiro
Aug 17, 2014·Trends in Endocrinology and Metabolism : TEM·Rohit A SinhaPaul M Yen
Sep 27, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Eveline BruinstroopAndries Kalsbeek
Jul 10, 2014·European Journal of Endocrinology·Eric FliersAnita Boelen
Apr 5, 2012·Canadian Journal of Physiology and Pharmacology·Luiz Fernando Paulino RibeiroEliete Luciano
Dec 17, 2009·Trends in Endocrinology and Metabolism : TEM·Eric FliersAndries Kalsbeek
Jun 20, 2015·Endocrine·Patricia Seoane-CollazoMiguel López
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Feb 13, 2016·The Journal of Endocrinology·Zhi ZhangEric Fliers
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Dec 24, 2018·European Thyroid Journal·Zhi ZhangEric Fliers

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