PMID: 2499289Jan 1, 1989Paper

Effects of thyrotropin-releasing hormone analogues on body shaking and prolactin levels in estrogen-primed and nonprimed rats

Archives Internationales De Pharmacodynamie Et De Thérapie
K YamadaT Furukawa

Abstract

The effects of a thyrotropin-releasing hormone (TRH) analogue, MK-771, in comparison with TRH and another TRH analogue, DN-1417, on body shaking and prolactin secretion were investigated in estrogen-primed and nonprimed rats. Intraperitoneal injections of TRH (20, 40 mg/kg), MK-771 (0.5-4 mg/kg) or DN-1417 (5-20 mg/kg) elicited marked body shaking in male rats. MK-771-induced shaking did not increase upon daily administration of the drug (0.5 mg/kg, s.c.) for 20 days or after treatment with estradiol benzoate (35 micrograms/kg, s.c.) for a 3 days period. Furthermore, following daily administration of MK-771 (0.5 mg/kg, s.c.) for 20 days, serum prolactin levels remained unchanged in male rats. Behaviorally active doses of TRH (20 mg/kg, i.p.), MK-771 (2 mg/kg, i.p.) and DN-1417 (10 mg/kg, i.p.) also failed to elevate serum prolactin levels in both ovariectomized rats and normal male rats. These drugs did, however, markedly elevate prolactin levels which had been increased in estrogen-primed male rats. The results suggest that TRH, MK-771 and DN-1417, in behaviorally active doses, exert a marked endocrine effect on prolactin secretion in estrogen-primed rats, but not in ovariectomized rats or normal male rats.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.