PMID: 6161384Jan 1, 1980Paper

Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography

Psychopharmacology
A SpissuG L Gessa

Abstract

The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequent fractions. On the contrary, no significant difference in 5-HIAA concentrations was found in sequential CSF samples. Tiapride increased the mean HVA concentrations and caused a steeper caudocranial gradient of this metabolite but failed to modify 5-HIAA concentrations. The results suggest that tiapride blocks dopamine (DA) receptors and increases DA synthesis.

References

Jan 1, 1978·The Journal of Pharmacy and Pharmacology·P JennerC D Marsden
May 1, 1977·Neuropharmacology·P N ElliottR Miller
Jul 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·R SjöströmE Anggård
Jun 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·E Garelis, T L Sourkes
Aug 1, 1973·Journal of Neurology, Neurosurgery, and Psychiatry·E Garelis, T L Sourkes
Jan 1, 1970·Brain : a Journal of Neurology·A T MoirH C Guldberg
Aug 20, 1971·Science·M Bulat, B Zivković
Apr 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·D EcclestonT B Crawford

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.