Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys

Menopause : the Journal of the North American Menopause Society
Petra StuteJ Mark Cline

Abstract

To evaluate the long-term effects of tibolone on estrone sulfate (E1S)-sulfatase activity in breast tissue in a primate model (Macaca fascicularis) in comparison with conventional hormone therapies. Ovariectomized female animals (n = 112) were randomized into five groups and treated for 2 years. Treatment included tibolone at 0.05 mg/kg (LoTib, n = 23) or 0.2 mg/kg (HiTib, n = 23), conjugated equine estrogens at 0.042 mg/kg (CEE, n = 24), CEE + medroxyprogesterone acetate at 0.167 mg/kg (CEE+MPA, n = 21), or placebo (controls, n = 21). E1S-sulfatase activity was evaluated by incubating homogenized breast tissue with [H]-E1S. Thin-layer chromatography was performed to separate the products estrone (E1) and estradiol (E2). Histomorphometry was performed to measure the amount of epithelial and fat tissue in the mammary gland. Significantly more E2 than E1 was produced in all groups. E1S-sulfatase activity did not differ among the groups. E1S-sulfatase activity was highest in HiTib animals with less fatty breasts (5.9 fmol total estrogen/mg of protein/min; P < or =0.05) and lowest in HiTib animals with more fatty breasts (2.8 fmol total estrogen/mg of protein/min; P = 0.004 relative to less fatty breasts). We conclude that tibolone...Continue Reading

References

Feb 1, 1979·Steroids·Y J Abul-HajjD T Kiang
Sep 1, 1991·Maturitas·A R GenazzaniL Tax
Jan 1, 1985·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S Partanen
Apr 1, 1988·Journal of Steroid Biochemistry·E PerelD W Killinger
Nov 1, 1985·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·R Hobkirk
Jan 1, 1985·Breast Cancer Research and Treatment·R A HawkinsE Killen
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·T L DaoP R Libby
Apr 1, 1980·Endocrinology·F VignonH Rochefort
Oct 1, 1983·Journal of Steroid Biochemistry·L TsengM L Stone
Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·S J SantnerR J Santen
Oct 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N WilkingO Tollbom
Jan 1, 1995·Maturitas·J GinsburgS Okolo
Feb 1, 1995·Obstetrics and Gynecology·D GradyD Petitti
Jun 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·H J KloosterboerJ G Klijn
Mar 1, 1994·British Journal of Cancer·T R EvansR C Coombes
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·G SöderqvistK Carlström
Jan 1, 1996·American Journal of Obstetrics and Gynecology·J M ClineB von Schoultz
Aug 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·T R EvansR C Coombes
Dec 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G M PrelevicJ Ginsburg
Jan 1, 1997·Breast Cancer Research and Treatment·S ImotoY Ishimura
May 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K LippunerP Jaeger
May 23, 1998·Breast Cancer Research and Treatment·J M ClineB von Schoultz
Jul 17, 1998·Drugs·K A McKinney, W Thompson
Dec 16, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·P ZandbergD G Meuleman
Mar 25, 2000·The Journal of Steroid Biochemistry and Molecular Biology·G S ChetriteJ R Pasqualini
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·T UtsumiN Harada
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·G S Chetrite, J R Pasqualini
Oct 18, 2001·Molecular and Cellular Endocrinology·M E de GooyerH J Kloosterboer
Jan 16, 2002·Menopause : the Journal of the North American Menopause Society·J Koudy WilliamsThomas B Clarkson
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Heidi D NelsonJanet D Allan
Nov 20, 2002·Menopause : the Journal of the North American Menopause Society·J Mark ClineThomas B Clarkson
Dec 12, 2002·Steroids·Marcel E de GooyerHelenius J Kloosterboer
Dec 21, 2002·Biology of Reproduction·Francis L Bellino, Phyllis M Wise

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Citations

Aug 12, 2014·Journal of Enzyme Inhibition and Medicinal Chemistry·Petra StuteMartin Götte
Sep 26, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Martin GöttePetra Stute
Jun 6, 2007·Maturitas·Petra StuteWalter Klockenbusch
Dec 1, 2008·Toxicologic Pathology·J Mark Cline, Charles E Wood
Apr 11, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·H A M VerheulH J Kloosterboer

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