PMID: 6408650Apr 1, 1983Paper

Effects of time and experience on hippocampal neurochemistry after damage to the CA3 subfield

Pharmacology, Biochemistry, and Behavior
G HandelmannC J Cummins

Abstract

Bilateral injections of kainic acid into the hippocampal CA3 subfield destroyed the CA 3 pyramidal cells and produced a behavioral impairment, an inability to solve spatial maze problems. The behavior recovered, however, with daily experience in a maze task, and the rate of recovery was accelerated by additional daily experience. This recovery of function could be the result of compensatory changes in the distribution or function of the various hippocampal pathways. In the present experiment, this possibility was investigated neurochemically. Five putative neurotransmitters or their synthetic enzymes were measured in dissected regions of the hippocampal formation. Both the long-term effects of the lesions and the effects of behavioral training were determined. A number of alterations in hippocampal neurochemical systems were detected. Acute changes due to the lesions included a widespread loss of glutamate, and regionally specific decreases in glutamic acid decarboxylase (GAD) activity and cholecystokinin (CCK) and norepinephrine (NE) concentrations. Long-term changes included a decline in choline acetyltransferase (ChAT) activity throughout the hippocampal formation, and increases in NE in certain regions. Behavioral testing p...Continue Reading

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Citations

Jan 1, 1985·Behavioral and Neural Biology·F Schenk
Mar 1, 1979·Clinical Allergy·C W Clarke, P M Aldons
Oct 1, 1983·Neuropeptides·M C Beinfeld
Jun 1, 1985·Scandinavian Journal of Dental Research·C Stecksén-Blicks
Feb 1, 1980·Scandinavian Journal of Dental Research·M Svanberg
Mar 1, 1984·Clinical and Experimental Dermatology·P J CoenraadsH Lantinga
Apr 1, 1985·British Journal of Haematology·S A Larsson
Jul 28, 2006·Biochemical and Biophysical Research Communications·Qiu-Ling HouBao-Ming Li
May 7, 2002·Neurobiology of Learning and Memory·Henry YinJohn G Csernansky
Jan 1, 1985·Critical Reviews in Toxicology·S C Bondy
Jun 4, 2013·Journal of Nutritional Science and Vitaminology·Panicha ThanapreedawatHidehiko Yokogoshi
Jan 15, 1989·The Journal of Comparative Neurology·K B Seroogy, J H Fallon

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