PMID: 2484756Jun 1, 1989Paper

Effects of tin and lead on organ levels of essential minerals in rabbits

Biological Trace Element Research
G Zareba, J Chmielnicka

Abstract

The effect of tin and lead on levels of essential metals (Zn, Cu, Ca, Fe) in rabbit tissues was compared in relation to the route of administration. Animals received intraperitoneally, or per os, SnCl2 (2 mg Sn/kg) or Pb(CH3COO)2 (3.5 mg Pb/kg) every day for 5 d or for 1 mo. Copper, zinc, iron, and calcium were determined by AAS in the liver, kidneys, spleen, brain, bone marrow, and blood; lead and tin concentration were measured in the blood of animals. Tin and lead administered per os caused either no changes or the decreased concentration of endogenous metals in several tissues. The other route of administration (ip) of both metals generally contributed to the increased storage of essential elements. Blood tin levels of tin treated animals were only about less than or equal to 1/10 of blood lead concentrations of rabbits exposed to lead.

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Citations

Jan 1, 1993·Biological Trace Element Research·J ChmielnickaA Korycka
Aug 1, 1992·Biological Trace Element Research·G Zareba, J Chmielnicka
Nov 1, 1994·Ecotoxicology and Environmental Safety·J ChmielnickaM Nasiadek
May 14, 2003·Ecotoxicology and Environmental Safety·Jadwiga Chmielnicka, Marzenna Nasiadek
Jul 23, 2008·Neurotoxicology·Anke Tomaszewski, Dietrich Büsselberg

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