PMID: 8454377Feb 1, 1993Paper

Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction

International Journal of Cardiology
J M KalanT J Ryan

Abstract

To assess the effects of reperfusion therapy on acute right ventricular myocardial infarction, we studied at necropsy the hearts from 51 patients who died after receiving intravenous recombinant tissue plasminogen activator for acute left ventricular myocardial infarction as part of the Thrombolysis in Myocardial Infarction (TIMI) study. Right ventricular infarction occurred in none of 29 patients with infarction of the anterior wall of the left ventricle and in 8 of 22 patients (36%) with infarction of the posterior (inferior) wall of the left ventricle. Of the 22 patients with posterior wall infarction, the 8 patients with right ventricular infarction were compared to the 14 patients without right ventricular infarction. The patients with right ventricular infarction had a longer mean interval from tissue plasminogen activator infusion to peak creatine phosphokinase level (19 vs. 11 h, P < 0.03), a lower frequency of hemorrhagic necrosis (2 of 8 vs. 10 of 14, P < 0.04) and higher frequency of luminal thrombus in the infarct-related coronary artery (6 of 8 vs. 3 of 14, P = 0.054). Each of these findings is associated with the absence of coronary reperfusion. Thus, successful reperfusion following acute left ventricular myocard...Continue Reading

References

Apr 1, 1978·The Journal of Clinical Investigation·S F VatnerP R Maroko
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Feb 1, 1980·The American Journal of Cardiology·N B Ratliff, D B Hackel
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Citations

May 1, 1994·Cardiovascular Drugs and Therapy·J López-SendónJ L Delcán
Jun 8, 2000·Applied Nursing Research : ANR·N JairathC Parsons
Jan 1, 1997·Memórias do Instituto Oswaldo Cruz·M A Lindsay, M A Giembycz
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Philip RileyHelen V Worthington

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