PMID: 7089984Jan 1, 1982Paper

Effects of tobacco smoke compounds on the ciliary activity of the embryo chicken trachea in vitro

Toxicology
B PetterssonC R Enzell

Abstract

The ciliotoxicity of 316 individual compounds representative of the gaseous and semivolatile phases of tobacco smoke has been investigated using chicken tracheal organ cultures. When examined at 5 mM concentration and measuring the time to complete ciliostasis, 36% of the compounds were found to cause ciliostasis within 15 min, while about 50% had no visible effect on the ciliary activity during a 60-min exposure. The majority of the ciliotoxic compounds were either alkylated phenylethers, benzonitriles, benzaldehydes, phenols, benzenes, naphthalenes and indoles, or alpha, beta-unsaturated ketones and aldehydes or C6-C10 aliphatic alcohols, aldehydes, acids and nitriles. Most of the compounds classified as benzoic acids, esters, polyaromatic hydrocarbons, amines and N-heterocycles, except indoles, were found to be inactive.

Citations

Sep 1, 1994·Journal of Applied Toxicology : JAT·P BonnetF Ganaire
Sep 1, 1983·Chemico-biological Interactions·V S Bernson, B Pettersson
Sep 1, 1994·Toxicology Letters·B BrunsborgP Olsen
Jan 1, 1984·Journal of Toxicology and Environmental Health·M CurvallM Thelestam
Sep 30, 2005·Reproductive Biology and Endocrinology : RB&E·Prue Talbot, Karen Riveles
Oct 2, 2019·BMJ : British Medical Journal·Jeffrey E GottsRobert Tarran

Related Concepts

Sodium Methoxide
Metazoa
Chick Embryo
Cilia
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Nicotiana tabacum
Trachea

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