PMID: 641265May 1, 1978Paper

Effects of tolerogenic conjugates in a canine model for reaginic hypersensitivity. I. suppression of hapten-specific IgE antibody response

The Journal of Allergy and Clinical Immunology
K S TseA H Sehon

Abstract

Intraperitoneal administration to dogs of conjugates consisting of the 2,4-dinitrophenyl (DNP) groups coupled to nonimmunogenic macromolecules such as the copolymer of D-glutamic acid and D-lysine (DNP16-DGL) prior to sensitization with DNP2-ovalbumin led to the development of hapten-specific tolerance with respect to the IgE antibody response. Administration of these same conjugates to sensitized dogs resulted in complete abrogation of the ongoing anti-DNP IgE antibody production. A similar hapten-specific suppression of the ongoing anti-DNP response was also observed using the conjugates of DNP9-canine gamma globulins, and the tolerogenic effect was dose-dependent. The state of hapten-specific immunosuppression induced by these two types of tolerogenic conjugates was maintained despite repeated booster injections of the sensitizing antigens at biweekly inervals.

Citations

Jan 1, 1978·Journal of Immunological Methods·E S RectorA H Sehon
Nov 1, 1979·Clinical Allergy·A H Sehon, W Y Lee
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·A H Sehon, W Y Lee
Dec 1, 1990·Clinical and Experimental Immunology·D M Kemeny, D Diaz-Sanchez

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