Effects of Tongxinluo on myocardial fibrosis in diabetic rats

Journal of the Chinese Medical Association : JCMA
Xiaomei WangZhimian Zhang

Abstract

The aim of this study was to explore the effect of Tongxinluo on myocardial fibrosis in diabetic rats and its possible mechanism of action. Diabetic rat models were established and then divided into three groups: control, diabetes, and Tongxinluo groups. Heart function and myocardial interstitial collagen volume fraction were investigated, and the protein and mRNA expression levels of transforming growth factor beta 1 (TGF-β1), Smad3, and Smad7 were measured. Heart function was clearly abnormal in the diabetes group compared with that in the control group, and the collagen volume fraction and mRNA expression levels of TGF-β1 and Smad3 were higher. However, the protein and mRNA expression levels of Smad7 were lower. In the Tongxinluo group, it was observed that these indicators were improved. Tongxinluo was effective for the prevention and treatment of myocardial fibrosis in diabetic rats. It probably mediates the expressions of TGF-β1, Smad3, and Smad7 in rat cardiomyocytes to reduce the occurrence of myocardial fibrosis in diabetic rats.

References

Nov 8, 1972·The American Journal of Cardiology·S RublerA Grishman
Aug 6, 2004·Endocrine Reviews·Zhi You FangThomas H Marwick
Jun 14, 2005·Cardiovascular Research·Daniela SchneidersGerhild Taimor
Aug 19, 2005·Cardiovascular Research·Gerhild Euler-Taimor, Jacqueline Heger
Jul 16, 2008·Current Diabetes Reports·Romain Harmancey, Heinrich Taegtmeyer
Aug 5, 2008·Vascular Pharmacology·Jason N Peart, John P Headrick
Aug 30, 2008·The American Journal of Medicine·Ashish AnejaMichael E Farkouh
Oct 2, 2008·Vascular Health and Risk Management·Camelia R Ban, Stephen M Twigg
Jul 15, 2009·Journal of Molecular and Cellular Cardiology·Lisandro Maya, Francisco J Villarreal
Oct 29, 2009·Orvosi hetilap·András Nagy, Zsuzsanna Cserép
Oct 1, 2010·Cardiovascular Research·Esther E Creemers, Yigal M Pinto
Jun 1, 2011·Heart Failure Reviews·Inês Falcão-Pires, Adelino F Leite-Moreira
Aug 28, 2012·Circulation. Arrhythmia and Electrophysiology·Sophie CardinStanley Nattel
Sep 4, 2012·International Journal of Molecular Sciences·Chunguo JiangZuojun Xu
Sep 11, 2012·The International Journal of Biochemistry & Cell Biology·Haihai LiangBaofeng Yang
Sep 22, 2012·Biochemical and Biophysical Research Communications·Jiang-Wen LiuYing Su
Apr 24, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Vishalakshi ChavaliParas K Mishra

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