Effects of tooth loss on brain structure: a voxel-based morphometry study

Journal of Prosthodontic Research
Takuya KobayashiHisatomo Kondo

Abstract

One of the most prominent issues in a super-aging society is the rapid increase in dementia patients. Cross-sectional studies in dentistry have indicated that patients with dementia have worse oral health compared to healthy people. The purpose of this study was to clarify the influence of tooth loss on brain structure by comparing the volumes of gray matter (GM) and white matter (WM) between edentulous and dentulous subjects. Subjects were recruited from the Denture Clinic at Iwate Medical University Hospital Dental Center. Experiments were performed on edentulous (5 males, 8 females, 81.8±1.24years) and dentulous subjects (4 males, 7 females, 77.1±4.25years). Patients with dementia were excluded from this study. Brain volumes of GM and WM in edentulous and dentulous subjects were compared using intracranial volume, age, gender and history of hypertension as covariates. Analyzed brain areas were identified by transforming the Montreal Neurological Institute coordinate into the anatomical coordinate in edentulous subjects. The analysis of WM structural images found no morphological differences between dentulous and edentulous subjects. However, significant atrophy of GM was observed in the hippocampus, caudate nucleus and tempo...Continue Reading

References

May 12, 2000·Neuroscience Letters·S A RomboutsP Scheltens
May 9, 2006·Gerodontology·Helen Adam, Antony J Preston
Sep 5, 2007·Journal of the American Geriatrics Society·Robert Stewart, Vasant Hirani
Oct 3, 2007·The Journal of the American Dental Association·Pamela Sparks SteinRichard J Kryscio
May 1, 2008·Hippocampus·Kaoruko YamazakiTetsuya Suzuki
May 31, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bei WuJersey Liang
Jun 23, 2009·Journal of Clinical Periodontology·Hans Joergen GrabeThomas Kocher
Apr 1, 2006·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Margaret GatzNancy L Pedersen
Dec 17, 2009·Neurobiology of Aging·Luiz K FerreiraMarcus V Zanetti
Mar 20, 2010·Journal of Oral Rehabilitation·Y OnoM Onozuka
Mar 24, 2010·Journal of Alzheimer's Disease : JAD·Balenahalli N RameshK S Jagannatha Rao
Jul 8, 2010·Gerodontology·Anna-Maija Hannele SyrjäläMatti Knuuttila
Oct 5, 2010·Geriatrics & Gerontology International·Takeshi KikutaniHidetada Sasaki
Nov 26, 2010·Neurology·J L WhitwellK A Josephs
Dec 24, 2010·Okajimas Folia Anatomica Japonica·Kin-Ya KuboYasuo Tamura
Jun 16, 2012·Journal of Alzheimer's Disease : JAD·Jing YangHui-Fang Shang
Mar 14, 2013·European Journal of Public Health·Sandra Feodor NilssonMerete Nordentoft
May 15, 2013·European Journal of Radiology·Sudevan JijiRamapurath S Jayasree
Jun 19, 2013·Behavioural Brain Research·Hiroshi OueYasumasa Akagawa
Oct 18, 2014·Journal of Alzheimer's Disease : JAD·Christiane MöllerHugo Vrenken
Dec 20, 2014·Journal of the American Geriatrics Society·Georgios TsakosPanayotes Demakakos
Jun 17, 2015·International Journal of Medical Sciences·Huayue ChenKin-Ya Kubo
Dec 1, 2015·PloS One·Min Soo ByunUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Pierre EustachePatrice Péran
Mar 25, 2016·Indian Journal of Psychological Medicine·Vinod VargheseThomas Gregor Issac
Apr 6, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xin HuangUNKNOWN Oculopathy fMRI study group
Feb 9, 2017·Journal of Clinical Neurology·Peter LeeUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Sep 22, 2019·Oral Diseases·Miranda E OrrXianlin Han
Feb 2, 2019·Journal of Prosthodontic Research·Mai IkutaPeter Svensson
Mar 15, 2020·Brain Imaging and Behavior·Chia-Shu LinJong-Ling Fuh
Nov 10, 2020·Journal of Neuroscience Research·Tomohisa NakamuraMakoto Michikawa
Mar 26, 2021·Journal of Prosthodontic Research·Ayaka NakasatoHisatomo Kondo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.