PMID: 9433939Jan 20, 1998Paper

Effects of topical anti-inflammatory drugs on eosinophil survival primed by epithelial cells. Additive effect of glucocorticoids and nedocromil sodium

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Joaquim MullolCesar Picado

Abstract

Eosinophil infiltration is a hallmark of the inflammatory response in rhinitis and in nasal polyposis. We studied the effect of steroids and nedocromil sodium on eosinophil survival primed by epithelial cells from healthy (nasal mucosa) and inflamed (nasal polyp) respiratory tissue. Blood eosinophils were incubated with increasing concentrations (10(-11)-10(-5) M) of topical steroids (fluticasone propionate, budesonide, triamcinolone acetonide and beclomethasone dipropionate) and/or nedocromil sodium prior to the addition of human epithelial cell conditioned media (HECM), eosinophil viability was measured and IC50 for each drug was calculated. All four steroids and nedocromil sodium caused a dose-related inhibition of HECM-induced eosinophil survival. The IC50 of steroids were lower in eosinophils primed by mucosa HECM than on those primed by polyp HECM (fluticasone, 4 nM vs 114 nM; budesonide, 21 nM vs 280 nM; triamcinolone, 7 nM vs 853 nM; and beclomethasone, 171 nM vs 181 nM). The combined inhibitory effect of 10(-7) M budesonide plus 10(-5) M nedocromil (43.8 +/- 10.8%, P<0.03) was significantly higher than budesonide (28.5 +/- 9.2%) or nedocromil (16.7 +/- 5.4%) alone and close to 10(-5) M budesonide (52.3 +/- 11%). No dif...Continue Reading

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Citations

Jan 26, 2012·Current Allergy and Asthma Reports·Isam Alobid, Joaquim Mullol
Jul 21, 2007·Southern Medical Journal·Stephen A Brunton, Leonard M Fromer
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·F M SpoelstraD S Postma
Jun 21, 2013·International Journal of General Medicine·Patorn PiromchaiSanguansak Thanaviratananich
Sep 21, 2013·Expert Opinion on Pharmacotherapy·Gwijde F J P M Adriaensen, Wytske J Fokkens
Dec 6, 2005·Otolaryngologic Clinics of North America·Valerie J Lund
Aug 26, 2010·The Annals of Otology, Rhinology, and Laryngology·Fuat TosunAbdullah Durmaz
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Mullol, C Picado
Dec 21, 2011·The Laryngoscope·Ahmed BassiouniPeter-John Wormald
Jul 29, 2006·American Journal of Rhinology·Yvonne FischerPhilipp M Gruen

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