PMID: 9449168Jan 1, 1997Paper

Effects of topical antiandrogen and 5-alpha-reductase inhibitors on sebaceous glands in male fuzzy rats

Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
F YeH Uno

Abstract

The fuzzy rat, a genetic mutant between hairless and hairy albino rats, expresses androgen-dependent hypersecretion of sebum and hyperplastic sebaceous glands. Using this model for human acne, we examined the effects of inhibitors of human steroid 5 alpha-reductase isozymes, type I (MK 386) and type II (finasteride), and an androgen receptor blocker (RU58841) on regression of glandular and ductal hyperplasia. The above three agents, 1% weight volume, were dissolved into the vehicle (propylene glycol, alcohol and water) and applied on the backs of peripubertal male rats for 2 months. Control and castrate groups received vehicle alone. At 8 weeks, we examined the size the sebaceous glandular lobules and ducts in split epidermal preparations as well as in frozen sections of skin stained with osmium-potassium dichromate solution. The number of bromodeoxyuridine (BrdU)-positive cells was counted in the glandular lobes in split-skin tissues stained with BrdU immunochemistry. The results revealed that the sizes of both lobes and ducts in castrates were 40-60% smaller than in controls. RU58841 induced glandular and ductal regression equivalent to that in castrates. Finasteride induced a moderate degree of lobular and ductal reduction, ...Continue Reading

Citations

Jul 26, 2012·Archives of Dermatological Research·Jiann-Jyh LaiChawnshang Chang
Feb 11, 2015·Expert Opinion on Drug Discovery·Zenildo SantosMichael R Hamblin
May 17, 2011·Journal of the American Academy of Dermatology·Hsien-Yi Chiu, Tsen-Fang Tsai
Oct 6, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Babette Biruss, Claudia Valenta
Jun 27, 2002·Expert Opinion on Pharmacotherapy·James C Shaw
Aug 28, 2014·Pharmaceutical Development and Technology·Ekapol LimpongsaThaned Pongjanyakul
Jul 12, 2017·Expert Opinion on Investigational Drugs·Hongwei GuoKevin John McElwee
Jan 25, 2019·Drug Discoveries & Therapeutics·Indu Lata KanwarVandana Soni
Oct 1, 2014·Current Opinion in Endocrinology, Diabetes, and Obesity·Elizabeth YimAntonella Tosti
Dec 8, 2011·Anais Brasileiros De Dermatologia·Sandra TagliolattoMauro Enokihara
Dec 3, 2013·Experimental Dermatology·Young Joon SeoMyung Im

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.