PMID: 7540967Mar 1, 1995Paper

Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat

Current Eye Research
N HikitaM Mochizuki

Abstract

FK506 is a macrolide antibiotic and a potent immunosuppressant. To investigate the effect of topical FK506 on acute ocular inflammation, we evaluated its action on the development of endotoxin-induced uveitis (EIU). At two different concentrations of 0.05% and 0.3%, topical FK506 was applied to Lewis rats with EIU. In aqueous, the mean number of inflammatory cells per microliter +/- SEM was 2,389 +/- 1,277, 1,571 +/- 1,562, 898 +/- 882, and 69 +/- 152 for rats treated with vehicle alone, 0.05%, 0.3% FK506, and 1% prednisolone acetate. The median of histological grades was 2, 1.5, 0.8, and 0.5 for animals treated with these 4 different regimens respectively. Analysis of aqueous protein showed a small reduction in FK506-treated animals. Mean blood levels of FK506 were low in rats treated with topical FK506 (0.05%, 0.84 ng/ml; 0.3%, 2.0 ng/ml) suggesting that its therapeutic effect was not secondary to the systemic absorption of the drug. Although FK506 is not as effective as prednisolone, 0.3% FK506 produced significant decreases in the mean aqueous inflammatory cell number and histological inflammatory score as compared to control vehicle alone. We conclude that topical FK506 can suppress EIU in a dose-dependent fashion and may ...Continue Reading

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Citations

Aug 25, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kenji ShiratoriShigeaki Ohno
Apr 9, 2005·Current Eye Research·Tomoaki IshikawaMasahiko Usui
Nov 11, 2009·Current Eye Research·Hiroaki MiyashitaKazuhisa Sugiyama
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·E LetkoA R Ahmed
May 10, 2015·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Bernardo Kaplan MoscoviciRichard Yudi Hida
Jul 10, 2008·Korean Journal of Ophthalmology : KJO·Young Joo ShinYoung Suk Sohn
Nov 27, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Eckart Bertelmann, Uwe Pleyer
Apr 19, 2012·Cornea·Bernardo K MoscoviciRichard Y Hida
Jul 22, 2009·The Journal of Experimental Medicine·Maria SemitekolouGeorgina Xanthou
Jan 20, 1999·Immunology and Cell Biology·J R SmithK A Williams
Jul 22, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhenyang ZhaoJiyang Cai
Nov 1, 1995·The British Journal of Ophthalmology·J T Rosenbaum
Mar 14, 2017·Eye and Vision·Samir S Shoughy
Oct 5, 2007·Annals of Ophthalmology·F Nilüfer YalçindağOzden Ozdemir

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