Effects of Topical Latanoprost on Intraocular Pressure and Myopia Progression in Young Guinea Pigs

Investigative Ophthalmology & Visual Science
Nevin W El-Nimri, Christine F Wildsoet

Abstract

To determine whether latanoprost, a prostaglandin analog proven to be very effective in reducing intraocular pressure (IOP) in humans, can also slow myopia progression in the guinea pig form deprivation (FD) model. Two-week-old pigmented guinea pigs underwent monocular FD and daily topical latanoprost (0.005%, n = 10) or artificial tears (control, n = 10) starting 1 week after the initiation of FD, with all treatments continuing for a further 9 weeks. Tonometry, retinoscopy, and high-frequency A-scan ultrasonography were used to monitor IOP, refractive error, and ocular axial dimensions, respectively. Latanoprost significantly reduced IOP and slowed myopia progression. Mean interocular IOP differences (±SEM) recorded at baseline and week 10 were -0.30 ± 0.51 and 1.80 ± 1.16 mm Hg (P = 0.525) for the control group and 0.07 ± 0.35 and -5.17 ± 0.96 mm Hg (P < 0.001) for the latanoprost group. Equivalent interocular differences for optical axial length at baseline and week 10 were 0.00 ± 0.015 and 0.29 ± 0.04 mm (P < 0.001; control) and 0.02 ± 0.02 and 0.06 ± 0.02 mm (P = 0.202; latanoprost), and for refractive error were +0.025 ± 0.36 and -8.2 ± 0.71 diopter (D) (P < 0.001; control), and -0.15 ± 0.35 and -2.25 ± 0.54 D (P = 0.03; ...Continue Reading

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Citations

Oct 3, 2018·Diseases·Aldo VaggeCarlo E Traverso
Jan 31, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Brittany J CarrWilliam K Stell
Mar 1, 2019·Investigative Ophthalmology & Visual Science·Christine F WildsoetJames S Wolffsohn
May 18, 2019·The British Journal of Ophthalmology·Kritchai VutipongsatornKyoko Ohno-Matsui
Sep 4, 2020·Vestnik oftalmologii·S E AvetisovL M Agaeva
Aug 28, 2020·BMC Ophthalmology·Li DongWen Bin Wei
Aug 3, 2019·American Journal of Ophthalmology·Wenjing WuYan Wang
Nov 5, 2019·Trends in Pharmacological Sciences·Tatiana V Tkatchenko, Andrei V Tkatchenko
Apr 29, 2021·Investigative Ophthalmology & Visual Science·Monica JongEarl L Smith
Jul 15, 2021·Eye and Vision·Yifang YangXingwu Zhong
Jul 21, 2021·Investigative Ophthalmology & Visual Science·Zhina ZhiXiangtian Zhou
Aug 28, 2021·Journal of Clinical Medicine·Silvia Mendez-MartinezMaría J Rodrigo
Nov 18, 2021·Investigative Ophthalmology & Visual Science·Peiyuan WangUNKNOWN GSHM study group

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