Effects of topical pilocarpine on ocular growth and refractive development in rabbits.

European Journal of Ophthalmology
Liyang TongJunwen Zeng

Abstract

This study aimed to investigate whether topical pilocarpine affects ocular growth and refractive development as well as the underlying biochemical processes in early eye development in rabbits. Twenty three-week-old New Zealand white rabbits were treated with 0.5% pilocarpine in the right eye for 6 weeks. The left eyes served as contralateral controls. The effects of pilocarpine on refractive error, corneal curvature and ocular biometrics were assessed using streak retinoscopy, keratometry, and A-scan ultrasonography, respectively. Eyeballs were enucleated for histological analysis. The ciliary body and sclera were homogenized to determine the mRNA and protein expression levels of five subtypes of muscarinic receptors. Compared to control eyes, pilocarpine-treated eyes exhibited approximately -1.63 ± 0.54 D myopia accompanied by a 0.11 ± 0.04 mm increase in axial length (AL) (p < 0.001, respectively). The anterior chamber depth (ACD) was reduced, whereas the lens thickness (LT) and vitreous chamber depth (VCD) increased (p < 0.001, respectively). Corneal curvature decreased over time but was not significantly different between treated and control eyes. The mRNA and protein expression levels of five subtypes of muscarinic recept...Continue Reading

References

Jun 1, 1991·Experimental Eye Research·R A StoneA M Laties
Sep 1, 1995·The Journal of Biological Chemistry·L A McKinnon, N M Nathanson
Oct 14, 1994·Brain Research. Developmental Brain Research·J B Hutchins
Jan 1, 1993·American Journal of Ophthalmology·P J ShumS L Lin
Jul 23, 1999·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M TiggesR A Stone
Feb 28, 2003·The Journal of Biological Chemistry·Alex GentleNeville A McBrien
Jun 9, 2005·Experimental Eye Research·Christina KoepplWolfgang Drexler
Mar 1, 2006·Investigative Ophthalmology & Visual Science·Edward A H MallenKaren M Hampson
Nov 26, 2008·Investigative Ophthalmology & Visual Science·Liqin JiangJia Qu
Dec 4, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zhi LinQianying Gao
Feb 18, 2010·Experimental Eye Research·Mark Wendt, Adrian Glasser
Jun 22, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Scott A ReadShiow-Huoy Cheong
Aug 23, 2011·Ophthalmology·Susan A CotterUNKNOWN Joint Writing Committee for the Multi-Ethnic Pediatric Eye Disease Study and the Baltimore Pediatric Eye Disease Study Group
Aug 23, 2011·Ophthalmology·Kristina Tarczy-HornochUNKNOWN Joint Writing Committee for the Multi-Ethnic Pediatric Eye Disease Study and the Baltimore Pediatric Eye Disease Study Group
Oct 17, 2012·Experimental Eye Research·Sohee JeonNam Ju Moon
Jan 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Atanu GhoshPayel Chatterjee
Feb 4, 2014·American Journal of Ophthalmology·Jianguang ZhongJianhua Wang
Aug 7, 2014·Investigative Ophthalmology & Visual Science·Lisa A OstrinChristine F Wildsoet
Nov 8, 2014·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Fang FangXiangtian Zhou
Oct 4, 2015·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Deborah S LaughtonLeon N Davies
Apr 16, 2016·Investigative Ophthalmology & Visual Science·Lucas J ListerDavid A Atchison
Aug 2, 2016·American Journal of Ophthalmology·Elise B CinerUNKNOWN Vision In Preschoolers - Hyperopia In Preschoolers (VIP-HIP) Study Group Writing Committee
Jul 25, 2018·Experimental Eye Research·Emily C Woodman-PieterseDavid Alonso-Caneiro
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongfang XieGuohui Wang

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Citations

Dec 29, 2021·European Journal of Ophthalmology·Guimei ZhouXuan Liao

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Methods Mentioned

BETA
protein assay

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