Effects of topical topiramate in wound healing in mice

Archives of Dermatological Research
Carlos Poblete JaraE Araujo

Abstract

Recent studies have indicated that systemic topiramate can induce an improvement on the aesthetic appearance of skin scars. Here, we evaluated topical topiramate as an agent to improve wound healing in C57/BL6 mice. Mice were inflicted with a 6.0 mm punch to create two wounds in the skin of the dorsal region. Thereafter, mice were randomly assigned to either vehicle or topical topiramate (20 µl of 2% cream) once a day for 14 days, beginning on the same day as wound generation. We analyzed the wound samples over real-time PCR, Western blotting, and microscopy. There was no effect of the topiramate treatment on the time for complete reepithelization of the wound. However, on microscopic analysis, topiramate treatment resulted in increased granulation tissue, thicker epidermal repair, and improved deposition of type I collagen fibers. During wound healing, there were increased expressions of anti-inflammatory markers, such as IL-10, TGF-β1, and reduced expression of the active form of JNK. In addition, topiramate treatment increased the expression of active forms of two intermediaries in the insulin-signaling pathway, IRS-1 and Akt. Finally, at the end of the wound-healing process, topiramate treatment resulted in increased expres...Continue Reading

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Citations

Jun 8, 2019·Experimental Dermatology·Christoph Abels, Michael Soeberdt
Apr 25, 2020·Journal of Tissue Engineering and Regenerative Medicine·Valéria C O PóvoaMarcelo G de Oliveira
Jun 13, 2020·Journal of Ethnopharmacology·Thalia Del Rosario Loyo CasaoJoão Paulo Viana Leite
May 27, 2021·Toxicology Reports·Saeed KadasahMohammed Arshaduddin

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