Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit

American Journal of Ophthalmology
H E KaufmanN G Bazan

Abstract

To determine the effect of the topical ocular hypotensive drug, isopropyl unoprostone, a docosanoid molecule with very weak prostaglandin activity, on herpes keratitis in the rabbit eye. For acute disease, rabbit corneas inoculated with the corticosteroid-sensitive F(MP)E strain of herpes simplex virus type 1 were treated with various combinations of 0.12% isopropyl unoprostone, latanoprost, trifluridine, benzalkonium chloride 0.02%, dexamethasone sodium phosphate, ketorolac tromethamine, or saline solution beginning 1 day after infection. Severity of keratitis was evaluated in a masked manner. For recurrent disease, rabbit corneas infected with McKrae strain herpes simplex virus type 1 were treated with unoprostone or saline solution on postinfection days 25 to 42, and the presence or absence of lesions was recorded. Eyes treated with unoprostone showed significantly less severe disease than saline-treated or latanoprost-treated eyes during acute infection. Unoprostone-treated and saline-treated eyes showed no significant difference in the frequency of recurrent lesions. Eyes treated with latanoprost and/or dexamethasone, separately or in combination, showed increased severity of acute herpes simplex virus keratitis, whereas b...Continue Reading

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Citations

Sep 3, 2002·Survey of Ophthalmology·Robert A SchumerAgneta K Mandahl
Jun 28, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Y Jerold GordonEric G Romanowski
Jul 28, 2011·The Ocular Surface·Charles S TresslerMichael A Lemp
Feb 22, 2012·Expert Opinion on Pharmacotherapy·Maurizio DigiuniLuca Rossetti
Mar 11, 2009·Current Eye Research·Shiro HigakiYoshikazu Shimomura
Aug 10, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lee S Peplinski, Karen Albiani Smith
Sep 9, 2004·Journal of Glaucoma·Gerald BeanThom J Zimmerman
Nov 26, 2010·Cornea·Sana S SiddiqueStephen Foster
Apr 24, 2007·International Ophthalmology Clinics·Relief JonesDeborah Pavan-Langston
May 26, 2007·Cornea·Irina S Barequet, Yael Wasserzug
Jun 20, 2003·Current Eye Research·Mary MarquartJames Hill
Jun 5, 2004·Journal français d'ophtalmologie·M Labetoulle

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