Effects of topically applied antioxidants in experimentally provoked polymorphous light eruption

Dermatology : International Journal for Clinical and Investigative Dermatology
I M HadshiewE Hölzle

Abstract

Polymorphous light eruption (PLE) is the most common photodermatosis, with a prevalence of 10-20% in Western European countries and in the USA. Only few preventive measures for PLE exist, while its etiology and pathogenesis are still elusive. Recent theories on pathogenesis discuss the possible influence of oxidative stress. The presented randomized, placebo-controlled, double-blind study examines for the first time the protective effect of 3 different topically applied antioxidative preparations in experimentally photo-induced PLE. 30 patients with a history of PLE underwent photoprovocation after having had applied 3 different formulations with antioxidants and one formulation with the vehicle only to the extensor surface of their upper arms, representing the individual site of predilection, twice daily for 1 week prior to and during the consecutive week of photoprovocation. The antioxidants used were combinations of different concentrations of alpha-glycosylrutin, ferulic acid and tocopheryl acetate. Evaluation after the 4th photoprovocation revealed that the development and severity of PLE and concomitant pruritus were significantly reduced by the application of distinct combinations of antioxidants. The results offer a new...Continue Reading

Citations

Dec 1, 2006·Journal of Cosmetic Dermatology·B Eberlein-König, J Ring
Sep 1, 2007·Advances in Skin & Wound Care·Darlene McCord, Jane Fore
Jun 24, 2011·Journal of the American Academy of Dermatology·Adrian TanewPiergiacomo Calzavara-Pinton
Feb 22, 2008·The Journal of Investigative Dermatology·Thomas P MillardJane M McGregor
Aug 22, 2000·The Journal of Investigative Dermatology·T P MillardJ M McGregor
Jun 6, 2003·The Journal of Investigative Dermatology·Swarna Ekanayake MudiyanselageJens J Thiele
Jul 9, 2004·Photodermatology, Photoimmunology & Photomedicine·I M HadshiewF Rippke
May 23, 2008·International Journal of Cosmetic Science·L E Rhodes, T M Callaghan
May 1, 2004·International Journal of Dermatology·Christina S SanderJens J Thiele
Oct 11, 2003·Photodermatology, Photoimmunology & Photomedicine·Tsui C LingLesley E Rhodes
May 15, 2008·Photodermatology, Photoimmunology & Photomedicine·Herbert Hönigsmann
Jan 10, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·M ZirbsB Eberlein
Nov 12, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Rainer WolberKlaus-Peter Wittern
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A J StratigosA D Katsambas
May 24, 2003·American Journal of Clinical Dermatology·Heike FesqDietrich Abeck
Mar 27, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Bernd HantkeHarald Tschesche
May 8, 2021·Indian Dermatology Online Journal·Kaliaperumal Karthikeyan, Manju Aishwarya

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