Effects of toxic doses of methamphetamine (METH) on dopamine D1 receptors in the mouse brain

Brain Research
J L CadetH Hirata

Abstract

Methamphetamine (METH) is a drug of abuse that causes marked DA depletion in the mammalian dopaminergic systems. These are characterized by marked decreases in presynaptic markers including dopamine (DA) levels and DA transporters. Very little research has been carried out to evaluate possible postsynaptic effects of this drug. In the present study, we assessed the status of METH on striatal DA D1 receptors labeled with [3H]SCH23390 after toxic doses of METH that were shown to cause marked depletion of various markers of presynaptic DA systems in mice [J. Neurochem. 69 (1997) 780]. Our results show that these doses of METH caused 30% decrease in striatal DA D1 receptors. In contrast, p53 knockout mice that show protection against the toxic effects of METH show no significant decreases in DA D1 receptors. These results suggest that toxic doses of METH that cause loss of presynaptic DA markers might also affect postsynaptic elements. We discuss the possibility that these changes might be secondary to toxic effects of METH on intrinsic striatal cell bodies.

References

Oct 1, 1989·Neuropharmacology·M J De Vito, G C Wagner
Jan 1, 1996·International Journal of Legal Medicine·M IwasaR Matoba

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Citations

Jul 20, 2010·Psychopharmacology·George KingLinda Chang
Apr 17, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Chun-Kai FangJeng-Jong Hwang
Mar 27, 2004·European Journal of Pharmacology·Victoria ArmstrongSanders A McDougall
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael P Caligiuri, Casey Buitenhuys
Feb 10, 2009·The European Journal of Neuroscience·Jun ChenAnita Sidhu
Oct 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa J MaddenHoward S Fox
May 10, 2019·Neurotoxicity Research·Yun-Hsiang ChenYun Wang
Jun 23, 2018·Brain Structure & Function·Michael Ohene-NyakoT Celeste Napier

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