Effects of traditional Chinese herbal medicine in patients with diabetic kidney disease: study protocol for a randomized controlled trial

Trials
Mengdi WangYaoxian Wang

Abstract

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus and the primary cause of end-stage renal disease. Existing therapies for DKD are not sufficiently effective. We report the protocol of a pragmatic randomized controlled trial of the use of traditional Chinese herbal medicine to treat patients with DKD. This will be a multicenter randomized controlled trial. A total of 266 patients with DKD (106 with early stage, 80 with middle-stage, and 80 with advanced-stage disease) with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m2will be included. Participants with DKD of each stage will be randomly allocated at a 1:1 ratio to either the experimental group, which will receive Xiaozhen formula and basic treatment, or the control group, which will receive basic treatment only. The study duration will be 24 weeks. The primary outcome will be urinary microalbumin excretion rate for early stage DKD, 24-h urinary protein for middle-stage DKD, and eGFR for advanced-stage DKD. Adverse events will also be evaluated. Data for all outcome indicators will be collected at baseline and weeks 4, 12, and 24. This study will provide evidence of the effectiveness and safety of traditional Chinese her...Continue Reading

References

Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Feb 20, 2010·Journal of the American Society of Nephrology : JASN·Johannes F E MannUNKNOWN ASCEND Study Group
Mar 1, 2012·The American Journal of Cardiology·James R RobertsDeborah A Marthers
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN National Kidney Foundation
Oct 30, 2012·The American Journal of Cardiology·Ana Montoro de FranciscoMiguel Puerro
Nov 6, 2012·The New England Journal of Medicine·Hans-Henrik ParvingUNKNOWN ALTITUDE Investigators
Jan 8, 2013·The Medical Clinics of North America·Anne T Reutens
Nov 12, 2013·The New England Journal of Medicine·Linda F FriedUNKNOWN VA NEPHRON-D Investigators
Jan 28, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J MacisaacGeorge Jerums
Apr 12, 2014·Journal of the American Society of Nephrology : JASN·Dick de ZeeuwHans-Henrik Parving
Dec 18, 2015·The Review of Diabetic Studies : RDS·Giorgina B PiccoliAndrea Veltri
Sep 1, 2016·The New England Journal of Medicine·Luxia ZhangHaibo Wang

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Citations

Jul 23, 2020·Journal of Diabetes Research·Dorin DragoșDorin Ionescu

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Methods Mentioned

BETA
ELISA

Software Mentioned

Statistic Package for Social Science ( SPSS
Epidata

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