PMID: 11912360Mar 26, 2002Paper

Effects of tranilast on filtering blebs: a pilot study

Journal of Glaucoma
Etsuo ChiharaSachiko Hamada

Abstract

To investigate the effects of topical instillation of 0.5% tranilast eye drops on intraocular pressure (IOP) and bleb formation after glaucoma filtering surgery. This was a prospective, randomized, double-masked, and controlled clinical trial. A total of 52 eyes of 52 patients were randomly assigned to receive either 0.5% tranilast eye drops (24 eyes) or vehicle saline solution (28 eyes) 4 times daily for 3 months after trabeculectomy. Features of the bleb, such as vascularization and size, and intraocular pressure were studied. The incidence of vascularized bleb and "pseudopod" formation 6 months post treatment were more common in tranilast-treated eyes than control eyes (P = 0.019 and P = 0.043, respectively). The bleb was significantly larger at 6 and 12 months (P = 0.024 and P = 0.049, respectively), and reduction of the IOP was more significant for 2 years postoperatively (P = 0.002 to P = 0.032) in tranilast-treated eyes than control eyes. No vision-threatening side reactions were associated with tranilast. The use of topical tranilast after filtering surgery alleviates ischemia of the filtering bleb, reduces IOP, and increases the size of the bleb.

References

Apr 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N KondoT Orii
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Y NakanoS Shirato
Oct 1, 1969·American Journal of Ophthalmology·W Van HerickA Schwartz
Oct 1, 1994·Journal of Biochemistry·H YamadaS R Pinnell
Aug 1, 1996·Archives of Ophthalmology·D S GreenfieldH W Flynn
Oct 14, 1996·Biochemical and Biophysical Research Communications·H IkedaK Fujiwara
Jan 30, 1999·The British Journal of Ophthalmology·H MietzM W Lieberman
Jan 1, 1984·Occupational Therapy in Health Care·J J Wamboldt

❮ Previous
Next ❯

Citations

Oct 17, 2012·Survey of Ophthalmology·Leonard K SeiboldMalik Y Kahook
Jan 29, 2016·BMC Ophthalmology·Osamu YamanakaPeter S Reinach
Jun 25, 2005·Journal of Cataract and Refractive Surgery·Jong-Suk SongHyo-Myung Kim
Apr 2, 2014·Medical Hypotheses·Amir Hossein NorooznezhadKimia Ahmadi
Dec 3, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sara Darakhshan, Ali Bidmeshki Pour
Apr 17, 2004·International Ophthalmology Clinics·Sean-Paul A AtreidesAdam C Reynolds
Mar 26, 2016·The Open Ophthalmology Journal·Masoumeh B MasoumpourM Reza Razeghinejad
Aug 12, 2020·Vestnik oftalmologii·V N GermanovaA V Zolotarev
Jun 7, 2020·International Ophthalmology·Camille Moura de Oliveira, Juliana de Lucena Martins Ferreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.