Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study

European Journal of Clinical Nutrition
J DyerbergS Stender

Abstract

Studies of long-term intake of industrially produced trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (PUFA) suggest opposite effects on cardiovascular disease risk. Common mechanisms of action are probable. To examine the effects on cardiovascular risk markers of dietary enrichment with TFA or n-3 PUFA. Randomized, double-blind, parallel intervention trial. Department of Human Nutrition, The Royal Veterinary and Agricultural University. In all, 87 healthy males included, 79 completed. Subjects were randomly assigned to 8 weeks of a daily intake of 33 g of experimental fats from either partially hydrogenated soy oil containing 20 g of TFA, 12 g of fish oil with approximately 4 g of n-3 PUFA and 21 g of control fat, or 33 g of control fat. The experimental fats were incorporated into bakery products. Plasma lipids, blood pressure, heart rate variability (HRV), arterial dilatory capacity, compliance, and distensibility were recorded before and after intervention and at follow-up 12 weeks after the intervention. High-density lipoprotein cholesterol (HDL-C) decreased in the TFA group and triglycerides and mean arterial blood pressure decreased in the n-3 PUFA group compared to the control group. HRV, arterial dilatory ca...Continue Reading

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References

Sep 1, 1991·The American Journal of Cardiology·R E KleigerJ L Fleiss
Jun 1, 1987·American Heart Journal·W B KannelL A Cupples
Jul 13, 1996·BMJ : British Medical Journal·A AscherioW C Willett
May 1, 1997·The American Journal of Clinical Nutrition·W S Harris
Nov 20, 1997·The New England Journal of Medicine·F B HuW C Willett
Jun 24, 1999·The New England Journal of Medicine·A AscherioW C Willett
Sep 9, 1999·The American Journal of Clinical Nutrition·J H ChristensenE B Schmidt
Feb 26, 2000·Journal of Internal Medicine·A ReunanenA Aromaa
Jul 17, 2001·Current Opinion in Cell Biology·A J PatelE Honoré
Jan 17, 2002·Mayo Clinic Proceedings·Brian M Curtis, James H O'Keefe
Feb 13, 2002·Circulation·Rozenn N LemaitreDavid S Siscovick
Apr 12, 2002·The New England Journal of Medicine·Christine M AlbertJing Ma
Jul 30, 2002·The American Journal of Clinical Nutrition·Paul NestelDaniel Raederstorff
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Aug 26, 2003·The American Journal of Clinical Nutrition·Jean-François MaugerBenoît Lamarche

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Citations

Aug 18, 2005·Current Atherosclerosis Reports·William S Harris
Nov 1, 2005·Current Atherosclerosis Reports·Frederick F Samaha
Oct 27, 2009·Current Atherosclerosis Reports·Sarah K Wallace, Dariush Mozaffarian
Nov 27, 2010·BMC Cardiovascular Disorders·Alexander KluttigKarin H Greiser
Apr 23, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bruce HolubDavid W L Ma
Dec 1, 2007·Clinical Interventions in Aging·Arthur V EverittDavid G Le Couteur
Dec 26, 2008·Food & Nutrition Research·Steen StenderJørn Dyerberg
Aug 2, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Eva TvrzickaAles Zak
May 10, 2012·Journal of Nutrition and Metabolism·Eman M Alissa, Gordon A Ferns
May 25, 2012·The British Journal of Nutrition·Lluis Serra-MajemKatalin Fekete
Feb 26, 2011·The Proceedings of the Nutrition Society·S C CottinW L Hall
Dec 2, 2015·Journal of Health Economics·Brandon J Restrepo, Matthias Rieger
Aug 22, 2006·The American Journal of Cardiology·Tricia L PsotaPenny Kris-Etherton
Aug 22, 2006·The American Journal of Cardiology·Jennifer G Robinson, Neil J Stone
May 23, 2006·Atherosclerosis. Supplements·Jørn DyerbergSteen Stender
Dec 12, 2012·Neurotoxicology·Beatriz ValeraEric Dewailly
Jul 28, 2015·Critical Reviews in Food Science and Nutrition·Yasmine Probst, Gail Zammit
Nov 5, 2011·Journal of the American College of Cardiology·Dariush Mozaffarian, Jason H Y Wu
Apr 15, 2015·Vascular Pharmacology·Maria Teresa La Rovere, Jeppe Hagstrup Christensen
Nov 7, 2014·The British Journal of Nutrition·Rebecca B CostelloChristopher T Sempos
Nov 6, 2013·Critical Reviews in Food Science and Nutrition·Balasubramanian GanesanDonald J McMahon
Sep 21, 2016·American Journal of Preventive Medicine·Jinnie J RheeTobias Kurth
Apr 29, 2009·Nature Reviews. Endocrinology·Renata Micha, Dariush Mozaffarian
Oct 7, 2009·Hypertension·Beatriz ValeraPaul Poirier
Feb 21, 2008·Circulation·Dariush MozaffarianDavid S Siscovick
Jul 10, 2012·Circulation. Arrhythmia and Electrophysiology·Luisa Soares-MirandaDariush Mozaffarian
Sep 21, 2005·Circulation·Dariush MozaffarianMartijn B Katan

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