Effects of trans and conjugated LC N-3 polyunsaturated fatty acids on lipid composition and abdominal fat weight in rats

Journal of Food Science
T OkadaK Miyashita

Abstract

Trans and conjugated fatty acids may exhibit either beneficial or detrimental bioactive effects depending on their metabolic properties. This study was conducted to elucidate if isomerization and conjugation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) demonstrate more favorable bioactivity on lipid metabolism compared to unmodified EPA and DHA. The effects of dietary intake of trans and conjugated forms of EPA and DHA on lipid metabolism were evaluated in animal trials and compared to a control group fed soybean oil. None of the experimental diets showed significant differences from the control in terms of body weight; however, the white adipose tissue weight of rodents fed trans DHA, conjugated EPA (CEPA), and conjugated DHA (CDHA) was significantly lower than the control. Triacylglycerol levels in plasma were significantly decreased in groups fed trans DHA (17.2 mg/dL) and CDHA (31.9 mg/dL) relative to the control (51.3 mg/dL). The total cholesterol concentrations were significantly lower than the control (68.0 mg/dL) in all experimental groups (47.3 to 53.7 mg/dL) except CEPA (58.3 mg/dL). Fatty acid compositions of lipids extracted from rodent livers were influenced by the dietary fatty acid profiles, with...Continue Reading

References

Jan 5, 2002·Nutrition and Cancer·M L SlatteryJ D Potter
Sep 17, 2002·The Journal of Nutritional Biochemistry·Mary EvansMichael McIntosh
Dec 18, 2003·Annals of Nutrition & Metabolism·Steen Stender, Jørn Dyerberg
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Citations

Oct 27, 2009·Current Atherosclerosis Reports·Sarah K Wallace, Dariush Mozaffarian
Aug 7, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Kanta ChechiSukhinder K Cheema
Mar 13, 2016·Lipids·Alan A HennessyCatherine Stanton

Related Concepts

Epicholesterol
Diet
Docosahexaenoic Acid, Sodium Salt
Saturated Fat
Isomerism
Lipids
Liver
Triglycerides
Eicosapentaenoic Acid
Omega-3 Fatty Acids

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