Effects of transarterial chemoembolization combined with antiviral therapy on HBV reactivation and liver function in HBV-related hepatocellular carcinoma patients with HBV-DNA negative

Medicine
Kai WangCaifang Ni

Abstract

The aim of this study was to investigate the reactivation of the hepatitis B virus (HBV) following transarterial chemoembolization (TACE) in primary hepatocellular carcinoma (HCC) patients with HBV-DNA negative and to evaluate the effects of TACE combined with antiviral therapy. This prospective study involved 98 patients with HBV-related and HBV-DNA negative HCC (HBV DNA < 10 copies/mL) underwent TACE procedures with serial HBV DNA tests. Patients were divided into the antiviral treatment group and the no-antiviral group. The antiviral group received entecavir antiviral therapy, and the other group received no antiviral therapy. Two groups of patients were compared in rate of HBV reactivation and liver function before and after only 1 session of TACE in average 1-month follow-up after operation. P < .05 indicated differences with a statistical significance. HBV reactivation occurred in 11 patients in the nonantiviral group (11/47, 23.4%) but only 3 patients in the antiviral group (3/51, 5.9%, P < .05). On multivariate analysis, HBeAg-positive status, number of tumors more than 3, and absence of antiviral therapy were the independent risk predictor of HBV reactivation. Liver function indicators did not differ significantly betw...Continue Reading

References

Mar 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent Wai-Sun WongTony Shu-Kam Mok
May 28, 2011·European Journal of Gastroenterology & Hepatology·Zhuanbo LuoBing Ruan
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Apr 20, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-Q DanW Y Lau
Jun 1, 2012·Hepatology International·Yun-Fan LiawMasao Omata

❮ Previous
Next ❯

Citations

Mar 16, 2019·Digestive Diseases and Sciences·Jordan J Feld, Lisette A P Krassenburg
May 19, 2020·Antiviral Chemistry & Chemotherapy·Mohamed A Abd El AzizAntonio Facciorusso
Jul 19, 2019·IET Systems Biology·Yi Ding, Wen-June Wang
Jul 29, 2021·World Journal of Gastrointestinal Pharmacology and Therapeutics·Niraj James ShahKumar Pallav

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.