Effects of transdermal buprenorphine on patients-reported outcomes in cancer patients: results from the Cancer Pain Outcome Research (CPOR) Study Group

The Clinical Journal of Pain
Giovanni ApoloneFurio Zucco

Abstract

Pain still afflicts most cancer patients, mainly in the metastatic phases, and under-treatment is well documented. Transdermal delivery systems (TDS) containing fentanyl or buprenorphine could potentiality have advantages over oral and parenteral routes, but evidence from comparative trials are scanty. In the framework of a wider initiative, an Outcome Research Study was carried out in Italy in 2006 to evaluate the effects of various analgesic options, particularly buprenorphine TDS. This is a multicenter, open-label, prospective, nonrandomized study. Data were collected using a web-based standardized system, with a follow-up up of to 3 months. Pain intensity, the primary outcomes of the study, was measured using 11-point numerical rating scales from the Brief Pain Inventory. One-hundred ten centers recruited 1801 cases, most of which (60%) were receiving a strong opioid at the time of inclusion. Of these, 257 had TDS buprenorphine as first choice. Of the remaining 709 patients who at the time of inclusion were not on a strong opioid, 325 changed to a strong opioid and in 43% it was TDS buprenorphine. During the follow-up, physicians had to increase the dosage to control pain (average increase between 16% and 17%). About 34% of...Continue Reading

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Citations

Sep 16, 2010·The Clinical Journal of Pain·Maria Teresa GrecoUNKNOWN Cancer Pain Outcome Research Study Group (CPOR SG) Investigators
May 7, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Russell K Portenoy, Ebtesam Ahmed
May 20, 2017·Clinical Journal of Oncology Nursing·Jeannine M BrantLinda H Eaton
Jun 20, 2018·Scandinavian Journal of Pain·Stephen Butler

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