PMID: 7547241Oct 1, 1995Paper

Effects of transforming growth factor beta-1 on growth-regulatory genes in tumour-derived human oral keratinocytes

British Journal of Cancer
Ian C PatersonW Andrew Yeudall

Abstract

This study examined the effect of transforming growth factor beta-1 (TGF-beta 1) on c-myc, RB1, junB and p53 expression together with pRb phosphorylation, in carcinoma-derived and normal human oral keratinocytes with a range of inhibitory responses to this ligand. Amplification of c-myc was observed in eight of eight tumour-derived cell lines and resulted in corresponding mRNA expression. The down-regulation of c-myc expression by TGF-beta 1 predominantly reflected growth inhibition by TGF-beta 1, but in two of eight tumour-derived cell lines which were partially responsive to TGF-beta 1 c-myc expression was unaltered by this ligand. While RB1 mRNA levels were unaltered by TGF-beta 1, the ligand caused the accumulation of the underphosphorylated form of the Rb protein in all cells irrespective of TGF-beta 1-induced growth arrest. junB expression was up-regulated by TGF-beta 1 in cells with a range of growth inhibitory responses. All cells contained mutant p53. TGF-beta 1 did not affect p53 mRNA expression in both tumour-derived and normal keratinocytes and there was no alteration in p53 protein levels in keratinocytes expressing stable p53 protein following TGF-beta 1 treatment. The data indicate that TGF-beta-induced growth co...Continue Reading

Citations

May 26, 1999·The Journal of Pathology·R J Akhurst, A Balmain
Dec 1, 2001·The Journal of Biological Chemistry·Sarah M Jacobs-HelberStephen T Sawyer
Nov 2, 2001·The Journal of Biological Chemistry·Ken YagiMitsuyasu Kato
Dec 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·S S PrimeI C Paterson
Mar 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heli Ylä-OutinenJuha Peltonen
Aug 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·C S DruganS S Prime

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