Effects of transitory cognitive impairment on psychosocial functioning of children with epilepsy: a therapeutic trial

Developmental Medicine and Child Neurology
D MarstonM Fowler

Abstract

The authors report a trial of the use of anti-epileptic medication to treat possible cognitive deficits due to subclinical epileptiform EEG discharges in 10 children with psychosocial and educational problems associated with epilepsy. Medication intended to suppress the EEG discharges was added to the children's existing drug regime. In all instances, epileptiform activity, assessed by 24-hour periods of ambulatory monitoring, was reduced on active medication compared with placebo. In general, there was improvement of psychosocial function on active treatment: eight children improved, there was no change in one and one deteriorated. No psychosocial deterioration attributable to adverse effects of the medication was detected in those completing the trial. Despite possible confounding factors, the findings are in accordance with the view that subclinical EEG discharges can impair psychosocial function, which may be ameliorated by anti-epileptic medication.

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Citations

Sep 23, 2000·Epilepsia·A J Fowle, C D Binnie
Jun 26, 2001·Epilepsia·F M Besag
Aug 30, 2011·Clinical EEG and Neuroscience·J Gordon MillichapCynthia V Stack
Jun 26, 2001·Epilepsia·C D Binnie
Feb 23, 2002·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Frank M C Besag
Apr 14, 2006·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Laura TremmelUlrich Brandl
Nov 23, 2010·Epilepsia·Miya R AsatoBeatriz Luna
Nov 29, 2016·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ronald J SwatzynaGerald P Kozlowski
Jun 13, 2019·Irish Journal of Medical Science·Man WangSuiqiang Zhu
Nov 17, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Evangelos Pavlou, Anastasia Gkampeta
Dec 3, 2009·Expert Review of Neurotherapeutics·Hesham M HamodaJoseph Gonzalez-Heydrich
Oct 24, 2012·Journal of Korean Medical Science·Gun-Ha KimSo-Hee Eun
May 21, 2009·Pediatric Research·Sarah J Spence, Mark T Schneider
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xun ZhangAiping Zheng
Aug 16, 2003·Epilepsia·Martin HoltmannMartin H Schmidt
Nov 16, 2006·Epilepsia·Stephen Brown
Nov 24, 2017·Developmental Medicine and Child Neurology·Clemente VegaTobias Loddenkemper
Jun 23, 2016·Clinical Medicine Insights. Pediatrics·Richard E Frye, Daniel A Rossignol
Nov 14, 2020·Journal of the International Neuropsychological Society : JINS·Elisa CainelliClementina Boniver

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