PMID: 9529172Apr 7, 1998Paper

Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b

The Journal of Trauma
K MaekawaK Ono

Abstract

To examine (1) the effects of trauma on changes in neutrophil L-selectin and CD11b expression and on the levels of soluble L-selectin and (2) whether these alterations are different on leukocyte subpopulations in those patients who develop multiple organ dysfunction syndrome. Twenty patients with Injury Severity Score (ISS) > or = 16 and 15 patients with ISS score < 16 were studied. Arterial blood were collected serially after injury. The staining of leukocyte surface adhesion molecules was performed with antibodies against L-selectin and CD11b. Positive cell count and mean fluorescence intensity were determined by flow cytometry. Soluble L-selectin was measured using enzyme-linked immunosorbent assay. In patients with ISS > or = 16, neutrophil L-selectin expression showed an immediate increase, reaching peak levels between 3 to 4 hours after injury (p < 0.05 vs. patients with ISS < 16), followed by a gradual decrease. Plasma levels of soluble L-selectin reached peak levels at 6 hours after injury. However, in patients with ISS < 16, minimal changes in L-selectin expression and soluble L-selectin were observed. Neutrophil CD11b expression showed an immediate increase for the first 3 hours followed by a gradual increase up to 24...Continue Reading

References

Jan 1, 1992·The Journal of Surgical Research·C White-OwenG F Babcock
Aug 1, 1991·The Journal of Surgical Research·B O AndersonA H Harken
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U H von AndrianE C Butcher
Feb 1, 1987·Archives of Surgery·R K SimonsE S Lennard
Oct 1, 1985·Archives of Surgery·R J GorisJ S Gimbrère
Oct 1, 1984·The Journal of Clinical Investigation·M A GimbroneA I Schafer
Feb 1, 1993·The Journal of Clinical Investigation·M P Bevilacqua, R M Nelson
Jun 1, 1993·Clinical and Experimental Immunology·C White-OwenG F Babcock
Jul 1, 1996·Annals of Surgery·M HeinzelmannH C Polk
Jan 1, 1996·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·H E HøgevoldO Reikerås

❮ Previous
Next ❯

Citations

Aug 31, 2000·Critical Care Medicine·T H RainerR A Cocks
Jan 31, 2003·Expert Opinion on Investigational Drugs·Vinay K Sharma, R Phillip Dellinger
Feb 16, 2010·Langenbeck's Archives of Surgery·Katharina HolzerWolf-Otto Bechstein
Jul 1, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick PaulusKai Zacharowski
Nov 6, 2018·BMC Immunology·Dean HuggardEleanor J Molloy
Jun 6, 2019·World Journal of Emergency Surgery : WJES·Lillian HesselinkFalco Hietbrink
Jun 21, 2005·Journal of Cellular and Molecular Medicine·D M Smalley, K Ley
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrian A MaungJames A Lederer
Mar 17, 2007·Scandinavian Cardiovascular Journal : SCJ·B TraboldD Fröhlich
Dec 8, 2011·International Journal of Immunopathology and Pharmacology·F CardinaleR Bernardini
Jan 17, 2013·European Journal of Immunology·Alexander Zarbock, Jan Rossaint
Sep 26, 2019·Frontiers in Immunology·Esmaeil MortazIan M Adcock
Dec 3, 1999·European Journal of Clinical Investigation·T KernerH Gerlach
Jul 11, 2001·Critical Care Medicine·C E Hack, S Zeerleder
Aug 7, 2002·Critical Care Medicine·Kenneth Cruz, Steven M Hollenberg
Feb 26, 2011·Expert Review of Respiratory Medicine·Mario PerlAlfred Ayala
Oct 16, 2004·Critical Care Medicine·Lorenzo E Ferri
Aug 27, 2010·Surgery Today·Fumio KimuraMasaru Miyazaki
Nov 11, 2009·The Journal of Trauma·Stephanie A ValenteAaron J Clark
Nov 9, 2002·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·T ChaiworapongsaR Gomez
Nov 29, 2012·The Journal of Trauma and Acute Care Surgery·Guang JinHasan B Alam
Feb 14, 2002·Resuscitation·Timothy H Rainer
Jul 18, 2002·The Journal of Surgical Research·Koji SasajimaRyo Ogawa
Jun 12, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Michel Paul Johan TeubenUNKNOWN TREAT-Research Collaboration
Oct 19, 2004·Injury·Martijn van GriensvenHans-Christoph Pape
Aug 11, 2005·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Tanja BarkhausenMartijn van Griensven
Jul 7, 2005·Injury·Raj K BhatiaNicholas Topley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved