PMID: 2109275Mar 1, 1990Paper

Effects of treatment with a lithium-imipramine combination on components of adenylate cyclase in the cerebral cortex of the rat

Neuropharmacology
A MørkA Geisler

Abstract

This study was aimed at investigating the effects of treatment with a lithium-imipramine combination on the activity of adenylate cyclase in membranes from the cerebral cortex of the rat. Treatment with (1) lithium for 2 weeks, yielding a level of lithium in serum of 0.54 +/- 0.12 mmol/l, (2) imipramine for 4 weeks (10 mg/kg i.p. twice per day) and (3) a combination of the two drugs reduced isoprenaline-induced stimulation of adenylate cyclase by GTP, with a greater decrement with the combined treatment. None of the treatments exerted any effect on the activity of the enzyme stimulated by GTP alone. Lithium ex vivo inhibited the calcium (Ca2+)- and Gpp(NH)p-stimulated activity of adenylate cyclase, but imipramine ex vivo did not affect the activity of adenylate cyclase, stimulated by these activators. The lithium-imipramine treatment reduced Ca2(+)- and Gpp(NH)p-stimulated activity of adenylate cyclase, but this was not different from that observed in the lithium-treated group. In conclusion, the beta-adrenoceptor-stimulated adenylate cyclase was affected markedly by administration of lithium and imipramine together. In contrast to lithium ex vivo, imipramine ex vivo did not impair the activity of either the guanine nucleotide ...Continue Reading

References

Jan 1, 1988·Cell Biophysics·A Levitzki
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Jan 1, 1986·Current Topics in Cellular Regulation·R J Lefkowitz, M G Caron
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Citations

Jan 1, 1992·Psychopharmacology·E McCance-KatzG R Heninger
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·Y OdagakiI Yamashita
Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·A Mørk, A Geisler
Oct 16, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·O Kofman, Y Patishi
Jan 1, 1992·Pharmacology & Toxicology·A MørkP Hollund
Dec 3, 2003·Brain Research·M Laura CuffiJavier Forn
Nov 3, 2006·Biochimica Et Biophysica Acta·Lisa A Catapano, Husseini K Manji
Sep 25, 2019·Nature Reviews. Urology·Asif MuneerAlimuddin Zumla
Jul 13, 2006·Medicina clínica·Frederic Mármol
Sep 16, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frederic Marmol

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