Effects of treatment with etizolam 0.5 mg BID on cognitive performance: a 3-week, multicenter, randomized, double-blind, placebo-controlled, two-treatment, three-period, noninferiority crossover study in patients with anxiety disorder

Clinical Therapeutics
Maria Pia De CandiaBruno M Cesana

Abstract

Etizolam is an anxiolytic drug with a pharmacologic profile similar to that of the classic benzodiazepines. Neurochemical research suggests that etizolam may have selectivity for the subpopulation of Y-aminobutyric acid type A receptors associated with anxiety (ie, alpha1, beta2, gamma2). This property, plus its characterization as a ligand with fewer of the adverse events typical of full agonists (impaired cognitive function, tolerance, and dependence), led to its selection for this study. The primary aim of this study was to test for the noninferiority of etizolam 0.5 mg BID versus placebo in affecting cognitive function in patients with mild to moderate anxiety disorder of recent onset (<1 month). Anxiety measures and tolerability were also assessed. Patients between the ages of 18 and 65 years were eligible for enrollment. This double-blind, placebo-controlled study was performed in 5 centers in Italy using a 2-treatment, 3-period crossover design. Patients were randomized to 3-week sequences of either etizolam-placebo-placebo or placebo-etizolam-etizolam. They were evaluated at 4 scheduled visits (screening and days 7, 14, and 21). Cognitive function was assessed using scores from the Wechsler Adult Intelligence Scale (WAI...Continue Reading

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Citations

Jul 2, 2010·British Journal of Pharmacology·Emma L ScotterMichelle Glass
Mar 29, 2019·The Cochrane Database of Systematic Reviews·Johanna BreilmannMarkus Koesters
Apr 4, 2020·Drug and Alcohol Review·Suzanne Nielsen, Andrew McAuley
Jul 26, 2019·Journal of Clinical Monitoring and Computing·Taras I UsichenkoAndreas Nowak
Dec 18, 2020·Frontiers in Psychiatry·Stefano TamburinFabio Lugoboni
Sep 28, 2021·Journal of Analytical Toxicology·Christena Watts, Teri L Martin
Dec 1, 2010·Current Opinion in Psychiatry

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