Effects of treatment with ivabradine and atenolol on reproducibility of echocardiographic indices of left heart size and function in healthy cats

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
S C RiesenJ D Bonagura

Abstract

Data on reproducibility of echocardiographic indices in cats are commonly derived from studies in healthy, non-treated animals. However, medical treatment may alter reproducibility of such data possibly influencing interpretation of results of clinical trials assessing the effects of drugs on cardiovascular function. The objectives were therefore to investigate the effects of ivabradine and atenolol on reproducibility of echocardiographic indices of left heart function. Eight healthy cats. Repeated echocardiographic examinations were performed by two observers in mildly sedated cats at baseline and after four weeks of treatment (Group 1, ivabradine 0.3 mg/kg q12 h PO, n = 4; Group 2, atenolol 6.25 mg/cat q12 h PO, n = 4) in a prospective, double-blind, randomized study. Test reliability was determined by estimating measurement variability, within-day interobserver variability, and between-day intraobserver variability of all echocardiographic indices. Variability was expressed as coefficient of variation (CV) and the absolute value below which the difference between two measurements lay with 95% probability. Effects of treatments on variability were compared using linear mixed effects models ANOVA and Fisher's exact test. Overa...Continue Reading

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Citations

Jan 19, 2016·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Karsten E Schober, Valérie Chetboul
Nov 7, 2014·The Journal of Veterinary Medical Science·Hiroshi TakanoYoko Fujii
Nov 8, 2017·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·David DicksonMark Rishniw

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