PMID: 6988539Feb 1, 1980Paper

Effects of treatment with progesterone and oestradiol-17 beta on the endocrine pancreas in ovariectomized rats: ultrastructural variations in the B cells

The Journal of Endocrinology
L AertsM T Sutter-Dub

Abstract

The effects of progesterone and/or oestradiol treatment on the ultrastructural appearance of the pancreatic B cells has been studied in ovariectomized Wistar rats. A morphometric examination of the numberical density of dark and high granules in the B cells was therefore performed in each group of experimental rats as well as in control (olive oil-injected) rats. In the oestradiol-treated rats, and especially in the rats with combined oestradiol/progesterone treatment, the proportions of light and dark granules in the pancreatic B cells changed, compared with control values, in favour of the light granules. This increase in light granule content was comparable to changes in B cells during a pregnancy and it is suggested that the secretory activity of the B cells increases during pregnancy in a manner similar to that seen during oestradiol treatment.

Citations

Jul 8, 1985·Life Sciences·H S Bender, W R Chickering
Dec 1, 1995·Diabetes Research and Clinical Practice·C Nolan, J Proietto
Mar 13, 2010·Experimental Animals·Yukihito IshiiMutsuyoshi Matsushita
Apr 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·B A WalshJ C Rutledge

Related Concepts

Castration
Estradiol, (16 alpha,17 beta)-Isomer
Islets of Langerhans
Electron Microscopy
Progesterone, (9 beta,10 alpha)-Isomer

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