Effects of TRH and TRH analogues on the central regulation of breathing in the rat

Acta Physiologica Scandinavica
J HednerJ Jonason

Abstract

Respiratory activity was studied in rats during light halothane anesthesia. Thyrotropin releasing hormone (TRH) and two TRH analogues: the desamidated form (TRH-OH) and gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate (DN 1417) were administered intracerebroventricularly. TRH 0.5-5 micrograms induced a marked tachypnoea with a rapid onset and a duration of at least 20 min. DN 1417, a potent analogue of TRH with a very low TSH (thyroid stimulating hormone) releasing activity was more effective in stimulating respiratory frequency, while TRH-OH, regarded to have neither TSH releasing nor extra hypothalamic effects, at equimolar doses was unable to induce any changes in the respiratory pattern. When TRH was given into the fourth ventricle the dose response curve was slightly shifted to the left. In experiments employing the occluded breath technique, P0.1 was increased in the same magnitude as the mean inspiratory flow (VT/T1). The results also indicated an increase in the gain of the inflation reflex loop whereas the central bulbopontine setting for T1 and TTOT were not significantly changed. Local injection of TRH into the nucleus tractus solitarii induced a stimulation of respiratory frequency which was slowe...Continue Reading

References

Feb 15, 1979·European Journal of Pharmacology·D LundbergR A Mueller
May 1, 1979·Acta Physiologica Scandinavica·F KoivusaloH Karppanen
Jun 1, 1976·Pharmacology, Biochemistry, and Behavior·G W KraemerW T McKinney
Jul 14, 1977·The New England Journal of Medicine·A J BergerJ W Severinghaus
Jan 1, 1976·Life Sciences·W de Jong, M Palkovits
Jul 19, 1974·Science·A Winokur, R D Utiger
Aug 1, 1974·Endocrinology·C OliverJ C Porter
Oct 1, 1973·Journal of Applied Physiology·M M GrunsteinJ Milic-Emili
Nov 6, 1969·Biochemical and Biophysical Research Communications·J BolerA V Schally
Jun 1, 1971·Journal of Applied Physiology·P Lynne-DaviesJ Milic-Emili
Feb 1, 1980·Clinical and Experimental Hypertension : CHE·C GomesB Persson
Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·P WessbergJ Jonason
Apr 10, 1980·Nature·T HökfeltM Schultzberg
Aug 1, 1981·Acta Physiologica Scandinavica·T HednerD Lundberg
Dec 1, 1981·Acta Physiologica Scandinavica·Y YamamotoC von Euler
Nov 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H Gautier, M Bonora
Jan 1, 1980·Journal of Neural Transmission·J HednerD Lundberg
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L Eriksson, A Gordin
Jul 1, 1982·Pediatric Research·T HednerD Lundberg
Jul 30, 1982·European Journal of Pharmacology·J HednerD Lundberg
Jan 1, 1981·Biology of the Neonate·T HednerD Lundberg
Jan 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·J HednerD Lundberg
May 18, 1956·Acta Physiologica Scandinavica·U S VON EULER, B PERNOW

❮ Previous
Next ❯

Citations

Jan 1, 1987·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z Y LiH Z Hu
Mar 11, 1986·European Journal of Pharmacology·I PaakkariA L Sirén
May 3, 1990·European Journal of Pharmacology·S VonhofV M Labroo
Mar 1, 1985·Regulatory Peptides·E C GriffithsW Klootwijk
Dec 1, 1992·Brain Research Bulletin·M IwaseI Homma
Jul 7, 2000·Pharmacology & Therapeutics·A HajiM Okazaki
May 21, 2004·Nature Reviews. Neuroscience·George B Richerson
May 1, 1987·Acta Physiologica Scandinavica·J HednerG R Breese
Mar 1, 1991·Acta Physiologica Scandinavica·M NinkJ Beyer
Apr 1, 1987·Reviews in the Neurosciences·R J Guiloff
Mar 16, 2011·International Journal of General Medicine·Khalil AnsarinMohammadali M Shoja
Aug 21, 1995·The Journal of Comparative Neurology·S M MurphyI J Llewellyn-Smith
Jan 1, 1989·Annals of the New York Academy of Sciences·Y TachéT Ishikawa
Dec 12, 2002·Chest·Tarja Saaresranta, Olli Polo
Jul 4, 2008·Respiratory Physiology & Neurobiology·Matthew R Hodges, George B Richerson
Oct 1, 1988·General and Comparative Endocrinology·M S KreiderA P Fishman
May 28, 2013·Respiratory Physiology & Neurobiology·Levi P SowersGeorge B Richerson
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Sep 18, 1997·Journal of Applied Physiology·C L CreamE E Nattie
Nov 24, 1999·The American Journal of Physiology·D MutoloT Pantaleo
Sep 24, 1999·Neuroscience and Behavioral Physiology·A N InyushkinS A Chepurnov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here