PMID: 3366161Jan 1, 1988Paper

Effects of triamterene on serum and skeletal muscle electrolytes in diuretic-treated patients

European Journal of Clinical Pharmacology
L WidmannP O Wester


The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (greater than 1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triamterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.


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Feb 1, 1967·Journal of the American Geriatrics Society·A D BenderK B Hansen
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Jun 30, 1994·The New England Journal of Medicine·D S SiscovickE H Wagner
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Related Concepts

Diastolic Blood Pressure
Body Water
Diuretic Effect
Water-Electrolyte Balance

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