PMID: 3366161Jan 1, 1988Paper

Effects of triamterene on serum and skeletal muscle electrolytes in diuretic-treated patients

European Journal of Clinical Pharmacology
L WidmannP O Wester

Abstract

The effects on plasma and skeletal muscle electrolytes of the combination of triamterene 37.5 mg and hydrochlorothiazide 25 mg daily were studied in 19 patients on prior long-term (greater than 1 year) diuretic therapy for arterial hypertension and/or congestive heart failure. A further 20 patients fulfilling the same admission criteria were used as controls. Blood samples and skeletal muscle biopsies were taken before the study and after 6 months on therapy. The diuretic-treated group had a significant increase in skeletal muscle potassium and magnesium after 6 months on therapy as compared to the controls. Thus, the combination of triamterene and hydrochlorothiazide appeared effective in preserving the cellular content of potassium and magnesium on a long-term basis in the type of patient studied.

References

Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·L S Gettes
Feb 1, 1967·Journal of the American Geriatrics Society·A D BenderK B Hansen
Nov 13, 1982·British Medical Journal·J D Swales
Nov 1, 1980·The American Journal of Medicine·A Helgeland
Mar 29, 1980·British Medical Journal·D B Morgan, C Davidson
Mar 1, 1963·The Journal of Clinical Investigation·R WHANG, L G WELT

Citations

Jun 30, 1994·The New England Journal of Medicine·D S SiscovickE H Wagner
Jul 1, 1993·British Journal of Clinical Pharmacology·D L Davies, R Fraser
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G T SandersR Sanders

Related Concepts

Diastolic Blood Pressure
Body Water
Diuretic Effect
Polychemotherapy
Magnesium
Muscle
Potassium
Urocaudal
Water-Electrolyte Balance

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