Effects of triazolopyrimidine on lipid peroxidation and nitric oxide levels in the corticosteroid-impaired healing of rat tracheal anastomoses

Cell Biochemistry and Function
Gürbüz PolatUğur Atik

Abstract

Corticosteroids are used to reduce the oedema and prevent scar tissue formation of the upper airways by their ability to inhibit influx of inflammatory cells, limit capillary permeability and block collagen synthesis in the early stages of wound healing. Triazolopyrimidine (Trapidil) is an antiplatelet agent that acts in part as a phosphodiesterase inhibitor and as a competitive inhibitor of the platelet-derived growth factor (PDGF) receptor. Trapidil, with its vasodilator and NO releasing effect may have some potential to diminish the tissue injury. This study was carried out to evaluate the effects of trapidil (triazolopyrimidine) on lipid peroxidation and nitric oxide in the corticosteroid-impaired healing of tracheal anastomoses. Thirty-four adult Wistar rats were divided into five groups. The animals underwent tracheal transection and primary anastomoses. The groups were assigned as follows: group I, control, (GI, n = 6); group II, sham, (GII, n = 6); group III, dexamethasone, 0.1 mg kg(-1) twice daily intramuscularly, (GIII, n = 8); group IV, trapidil, 6 mg kg(-1) twice daily intraperitoneally (GIV, n = 7); group V, dexamethasone, 0.1 mg kg(-1) plus trapidil, 6 mg kg(-1) twice daily (GV, n = 7), for 1 week. After 1 week, ...Continue Reading

References

Sep 1, 1992·Journal of Cellular Biochemistry·J R PerezK R Cutroneo
Nov 15, 1990·Biochemical and Biophysical Research Communications·M Di RosaS Moncada
May 1, 1990·The Journal of Surgical Research·M J Koruda, R H Rolandelli
Mar 1, 1986·American Journal of Surgery·K JönssonB Zederfeldt
Aug 1, 1980·Prostaglandins and Medicine·T KawamuraH Ijichi
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Dec 1, 1993·Trends in Pharmacological Sciences·P J Barnes, I Adcock
Dec 1, 1994·Trends in Biotechnology·G H GoldmanG E Harman
Jun 1, 1996·The Journal of Surgical Research·M R SchafferA Barbul
Jan 1, 1996·Journal of the American Optometric Association·E Cheraskin
Jan 1, 1996·Annual Review of Nutrition·B Halliwell
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Dec 1, 1996·Pediatric Clinics of North America·M M Lesperance, G H Zalzal
Jun 1, 1997·The Surgical Clinics of North America·M B Witte, A Barbul
Jun 1, 1997·The Journal of Surgical Research·A E UllandM D Caldwell
Jul 15, 1997·The Journal of Surgical Research·M R SchäfferA Barbul
Sep 19, 1998·Free Radical Biology & Medicine·W H Koppenol
May 14, 1999·Plastic and Reconstructive Surgery·A L SkigenP S Stopperich
Sep 25, 1999·Archives of Biochemistry and Biophysics·E E KelleyC P Burns
Dec 20, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·D T EfronA Barbul
Mar 4, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D L WalnerR T Cotton
Mar 11, 2000·British Journal of Pharmacology·K ZacharowskiH Darius
Nov 14, 2000·Archives of Surgery·C WickeT K Hunt
Oct 11, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K BüyükafşarA Levent
Aug 17, 2002·Neurosurgery·Celal BagdatogluLulufer Tamer

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Citations

Jan 28, 2014·Current Therapeutic Research, Clinical and Experimental·Esra ErtanDerya Umit Talas
Jan 19, 2020·Interactive Cardiovascular and Thoracic Surgery·Elif DumanŞeyda Örs Kaya

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