Effects of triclosan and triclosan monophosphate on maximum specific growth rates, biomass and hydrolytic enzyme production of Streptococcus sanguis and Capnocytophaga gingivalis in continuous culture

The Journal of Antimicrobial Chemotherapy
J GreenmanD G Nelson

Abstract

Dental plaque species, Streptococcus sanguis and Capnocytophaga gingivalis, were grown in continuous culture with progressively increasing concentrations of triclosan or its phosphorylated derivative, triclosan monophosphate (TMP). For both organisms, the maximum specific growth rates decreased with increasing concentrations of triclosan or TMP until complete inhibition of growth occurred, which for S. sanguis was at 20 mg/L and 50 mg/L, and for C. gingivalis was at 10 mg/L and 5 mg/L for triclosan and TMP respectively. For both species, biomass levels remained approximately constant or, in some cases, increased slightly at low levels of triclosan or TMP. However, biomass levels then decreased significantly as the triclosan or TMP concentrations approached lethal levels. For S. sanguis, levels of hydrolytic enzymes (acid phosphatase, leucine aminopeptidase and esterase) generally remained approximately constant or increased with increasing concentrations of triclosan or TMP until close to inhibitory levels where enzyme levels were reduced. The ratio of extracellular soluble enzymes to cell-bound enzymes remained constant or increased slightly with increasing levels of triclosan or TMP. For C. gingivalis, production of hydrolyti...Continue Reading

Citations

Nov 9, 2010·Journal of Toxicology and Environmental Health. Part a·Pablo E A Rodríguez, Mónica S Sanchez
Aug 23, 2003·Journal of Periodontology·Junji SuzukiKatsuyuki Kozai
Apr 27, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Nicole M PalenskeEdward M Dzialowski
Jan 20, 2015·International Journal of Computational Materials Science and Engineering·Richard C Petersen
Feb 8, 2000·The Journal of Antimicrobial Chemotherapy·C van LoverenJ M ten Cate

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