PMID: 7086700Jul 1, 1982Paper

Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey

The Journal of Pharmacology and Experimental Therapeutics
J W McKearney


Squirrel monkeys responded under fixed-interval schedules in which the first response after a fixed time period resulted either in the delivery of a food pellet or in the termination of stimuli associated with impending electric shock delivery. tricyclic antidepressant drugs markedly increased responding in 3 of 10 monkeys studied; less marked but reliable increases in responding were seen with 3 others, whereas the remaining 4 monkeys showed no increases in responding. Increases in responding were observed with amitriptyline HCl (0.1-17 mg/kg), imipramine HCl (0.3-17 mg/kg), chlorimipramine HCl (0.3-17 mg/kg), nortriptyline HCl (1-17 mg/kg) and desmethylimipramine HCl (1-17 mg/kg). Amitriptyline was most potent and desmethylimipramine least potent. The pattern of individual differences in the effects of the antidepressants was matched by a similar pattern of differences in the effects of atropine sulfate (0.03-1.7 mg/kg) and scopolamine HBr (0.003-0.3 mg/kg). That is, atropine and scopolamine increased responding only in those monkey showing increases in responding with the antidepressant drugs. In contrast, all monkeys showed increases in responding with the histamine H1 antagonist diphenhydramine HCl (0.3-17 mg/kg). The orde...Continue Reading

Related Concepts

Tricyclic Antidepressive Agents
Operant Conditioning
Dose-Response Relationship, Drug
Antispasmodic Effect
Reinforcement Schedule
Genus Saimiri

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