PMID: 9166988Apr 1, 1997Paper

Effects of trimetazidine on the calcium transport and oxidative phosphorylation of isolated rat heart mitochondria

Basic Research in Cardiology
C GuarnieriC Muscari

Abstract

Trimetazidine (TMZ) added in vitro to isolated cardiac mitochondria at concentrations 10-100 microM in the presence of 25-100 nM extramitochondrial Ca2+ increased Ca2+ uptake and matrix Ca2+ concentration. This effect was less evident in the presence of physiologically Na+ and Mg2+ extramitochondrial concentrations since only 100 microM TMZ was able to increase mitochondrial Ca2+ entry in the presence of 100 nM Ca2+. The drug stimulated a Ca(2+)-cooperative effect on mitochondrial Ca2+ transport, but did not modify the rate of Ca2+ egress stimulated by 10 mM NaCl. An increase in mitochondrial Ca2+ level produced by TMZ enhanced oxoglutarate dehydrogenase activity and then ATP synthesis, particularly when 50 nM extramitochondrial Ca2+ was used. These data suggest that a possible cardiac mechanism of action of TMZ at mitochondrial level could support ATP synthesis by elevating the mitochondrial Ca2+ level.

Citations

Jul 31, 2004·Archives of Pharmacal Research·Mustafa EmreServet Kavak
Oct 27, 2009·Cardiovascular Toxicology·Nuno G MachadoPaulo J Oliveira
May 17, 2007·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Alexandra LabrouGeorge Louridas
Nov 20, 2013·TheScientificWorldJournal·Oytun ErbaşDilek Taşkıran
May 5, 2001·Expert Opinion on Pharmacotherapy·H R Cross
Nov 11, 2003·Current Medical Research and Opinion·Mario Marzilli
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Cian P McCarthyDavid M Kerins
Feb 27, 2007·Translational Research : the Journal of Laboratory and Clinical Medicine·Yin RuixingRasheed Al-Ghazali
Sep 14, 2006·Fundamental & Clinical Pharmacology·Ali F KaraAbdullah T Demiryürek
Jan 12, 2010·Journal of Applied Toxicology : JAT·Lilia Cristina De la Cruz RodríguezMaría Rosario Rey
Oct 22, 2004·European Journal of Pharmacology·Ali F KaraAbdullah T Demiryürek

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