Effects of triptorelin versus placebo on the symptoms of endometriosis

Fertility and Sterility
A BergqvistC Rasmussen

Abstract

To compare the effect of a GnRH-agonist, triptorelin, versus placebo on the symptoms of endometriosis. A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up. Departments of Obstetrics and Gynecology at two universities and one general hospital. Forty-nine women with symptoms of laparoscopically verified endometriosis. Triptorelin depot or placebo was given every 4 weeks. Clinical evaluation, including the Duration Intensity Behavior Scale and Visual Analogue Scale for pain, was performed before the injections and up to 12 months after treatment. A control laparoscopy was performed 4-6 weeks after the last injection. Quantitation of pain. Twenty-four patients had active treatment and 25 received placebo. Pain symptoms according to both scales were significantly more reduced after 2 months of triptorelin treatment compared to placebo. The extent of endometriotic lesions was reduced 50% during triptorelin treatment and increased 17% during placebo. The average area of endometriotic lesions was reduced 45% during triptorelin treatment but was unchanged during placebo. Side effects, mainly hot flushes, were experienced by 80% of the actively treated group but also by 33% of patient...Continue Reading

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