Effects of Trp- and Arg-containing antimicrobial-peptide structure on inhibition of Escherichia coli planktonic growth and biofilm formation.

Applied and Environmental Microbiology
Shuyu HouDacheng Ren

Abstract

Biofilms are sessile microbial communities that cause serious chronic infections with high morbidity and mortality. In order to develop more effective approaches for biofilm control, a series of linear cationic antimicrobial peptides (AMPs) with various arginine (Arg or R) and tryptophan (Trp or W) repeats [(RW)(n)-NH(2), where n = 2, 3, or 4] were rigorously compared to correlate their structures with antimicrobial activities affecting the planktonic growth and biofilm formation of Escherichia coli. The chain length of AMPs appears to be important for inhibition of bacterial planktonic growth, since the hexameric and octameric peptides significantly inhibited E. coli growth, while tetrameric peptide did not cause noticeable inhibition. In addition, all AMPs except the tetrameric peptide significantly reduced E. coli biofilm surface coverage and the viability of biofilm cells, when added at inoculation. In addition to inhibition of biofilm formation, significant killing of biofilm cells was observed after a 3-hour treatment of preformed biofilms with hexameric peptide. Interestingly, treatment with the octameric peptide caused significant biofilm dispersion without apparent killing of biofilm cells that remained on the surface;...Continue Reading

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Citations

May 31, 2011·Applied and Environmental Microbiology·Xi ChenDacheng Ren
Dec 29, 2013·Microbial Ecology·Lizziane Kretli WinkelströterElaine Cristina Pereira De Martinis
May 28, 2015·Applied Microbiology and Biotechnology·Ali Adem BaharDacheng Ren
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Nov 30, 2013·Pharmaceuticals·Ali Adem Bahar, Dacheng Ren
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Jul 4, 2019·Chemistry : a European Journal·Sina Rütschlin, Thomas Böttcher
Dec 19, 2019·Frontiers in Chemistry·Anthony D VerderosaKathryn E Fairfull-Smith
Dec 17, 2020·Biomedical Materials·Günnur OnakOzan Karaman
Jun 6, 2021·International Journal of Pharmaceutics·Li DingZhengrong Cui
Aug 8, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Huan GuDacheng Ren
Feb 16, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Shuyu HouDacheng Ren

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